Rotenoids from Boerhaavia diffusa as Potential Anti-inflammatory Agents

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• 作者：Khemraj Bairwa ; Ishwari N. Singh ; Somendu K. Roy ; Jagdeep Grover ; Amit Srivastava ; Sanjay M. Jachak
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：August 23, 2013
• 年：2013
• 卷：76
• 期：8
• 页码：1393-1398
• 全文大小：254K
• 年卷期：v.76,no.8(August 23, 2013)
• ISSN：1520-6025

文摘

Five new (2, 3, 5, 7, and 9) and four known rotenoids (1, 4, 6, and 8) were isolated from a methanol extract of Boerhaavia diffusa roots. The structures of the new rotenoids were elucidated by spectroscopic data interpretation. The 70% ethanol extract, a rotenoid-rich fraction, and all isolated rotenoids were evaluated for their COX-1 and COX-2 inhibitory activities. Among the rotenoids tested, compound 7 showed the most potent COX-1 and COX-2 inhibition, with IC₅₀ values of 21.7 卤 0.5 and 25.5 卤 0.6 渭M, respectively. Boeravinone B (6) exhibited significant anti-inflammatory activity (56.6% at 50 mg/kg) when evaluated in an in vivo carrageenan-induced rat paw model.