Preparation of Non-heme {FeNO}7 Models of Cysteine Dioxygenase: Sulfur versus Nitrogen Ligation and Photorelease of Nitric Oxide

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• 作者：Alison C. McQuilken ; Yang Ha ; Kyle D. Sutherlin ; Maxime A. Siegler ; Keith O. Hodgson ; Britt Hedman ; Edward I. Solomon ; Guy N. L. Jameson ; David P. Goldberg
• 刊名：Journal of the American Chemical Society
• 出版年：2013
• 出版时间：September 25, 2013
• 年：2013
• 卷：135
• 期：38
• 页码：14024-14027
• 全文大小：252K
• 年卷期：v.135,no.38(September 25, 2013)
• ISSN：1520-5126

文摘

We present the synthesis and spectroscopic characterization of [Fe(NO)(N3PyS)]BF₄ (3), the first structural and electronic model of NO-bound cysteine dioxygenase. The nearly isostructural all-N-donor analogue [Fe(NO)(N4Py)](BF₄)₂ (4) was also prepared, and comparisons of 3 and 4 provide insight regarding the influence of S vs N ligation in {FeNO}⁷ species. One key difference occurs upon photoirradiation, which causes the fully reversible release of NO from 3, but not from 4.