Isolation, Identification, and Bioactivity of Monoterpenoids and Sesquiterpenoids from the Mycelia of Edible Mushroom Pleurotus cornucopiae

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• 作者：Shaojuan Wang ; Li Bao ; Feng Zhao ; Quanxin Wang ; Shaojie Li ; Jinwei Ren ; Li Li ; Huaan Wen ; Liangdong Guo ; Hongwei Liu
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2013
• 出版时间：May 29, 2013
• 年：2013
• 卷：61
• 期：21
• 页码：5122-5129
• 全文大小：335K
• 年卷期：v.61,no.21(May 29, 2013)
• ISSN：1520-5118

文摘

Edible mushroom is a profilic source of bioactive metabolites for the development of drugs and nutraceuticals. In this work, four new monoterpenoids (1鈥?b>4) and one new sesquiterpenoid (6) were isolated from the mycelia of edible mushroom Pleurotus cornucopiae fermented on rice. Their structures were established by nuclear magnetic resonance, mass spectrometry, and circular dichroism (CD) data analysis. Compound 1 possesses an unusual spiro[benzofuran-3,2鈥?oxiran] skeleton. The absolute configuration of the 6,7-diol moieties in compounds 1, 2, and 6 was assigned using the in situ dimolybdenum CD method. Compounds 1鈥?b>5, 7, and 8 showed moderate inhibitory activity against nitric oxide production in lipopolysaccaride-activated macrophages, with IC₅₀ values in the range of 60鈥?0 渭M. Compounds 6 and 7 also exhibited slight cytotoxicity against HeLa and HepG2 cells.

Keywords:

Edible mushroom; Pleurotus cornucopiae; terpenoids; nitric oxide inhibition; cytotoxicity