Catalyst Chelation Effects in Organocatalyzed Ring-Opening Polymerization of Lactide

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• 作者：Daniel J. Coady ; Amanda C. Engler ; Hans W. Horn ; Krishna M. Bajjuri ; Kazuki Fukushima ; Gavin O. Jones ; Alshakim Nelson ; Julia E. Rice ; James L. Hedrick
• 刊名：ACS Macro Letters
• 出版年：2012
• 出版时间：January 17, 2012
• 年：2012
• 卷：1
• 期：1
• 页码：19-22
• 全文大小：208K
• 年卷期：v.1,no.1(January 17, 2012)
• ISSN：2161-1653

文摘

(鈭?-Sparteine is a proven organocatalyst for the ring-opening polymerization (ROP) of l-lactide, which affords polymers of controlled molecular weight and narrow polydispersity. The recent worldwide shortage of (鈭?-sparteine has necessitated the identification of simple and cost-effective replacement ROP catalysts. A series of commercially available molecules was first identified through molecular modeling and then subsequently investigated for polymerizing l-lactide. The modeling proved very useful at predicting spatial relationships and nitrogen geometries that greatly aided in the rapid identification of various alkyl amines as alternative organocatalysts.