Cerebrosides of the Halotolerant Fungus Alternaria raphani Isolated from a Sea Salt Field

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• 作者：Wenliang Wang ; Yi Wang ; Hongwen Tao ; Xiaoping Peng ; Peipei Liu ; Weiming Zhu
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：September 25, 2009
• 年：2009
• 卷：72
• 期：9
• 页码：1695-1698
• 全文大小：141K
• 年卷期：v.72,no.9(September 25, 2009)
• ISSN：1520-6025

文摘

In order to search for structurally novel and bioactive natural compounds from marine-derived fungi, a halotolerant fungal strain (THW-18) identified as Alternaria raphani was isolated from sediment collected in the Hongdao sea salt field. From the ethyl acetate extract of Alternaria raphani, three new cerebrosides, alternarosides A−C (1−3), and a new diketopiperazine alkaloid, alternarosin A (4), together with 15 known compounds were isolated and identified by spectroscopic and chemical methods, as well as X-ray crystal diffraction analysis. Compounds 1−4 showed weak antibacterial activity against Escherichia coli, Bacillus subtilis, and Candida albicans with MIC values ranging from 70 to 400 μM.