Diterpenoids from the Flowers of Rhododendron molle

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• 作者：Shuai-Zhen Zhou ; Sheng Yao ; Chunping Tang ; Changqiang Ke ; Lu Li ; Ge Lin ; Yang Ye
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：May 23, 2014
• 年：2014
• 卷：77
• 期：5
• 页码：1185-1192
• 全文大小：357K
• 年卷期：v.77,no.5(May 23, 2014)
• ISSN：1520-6025

文摘

A new seco-kalmane-type diterpenoid, seco-rhodomollone (1), five new grayanane-type diterpenoids, rhodomollein XXI (2), 6-O-acetylrhodomollein XXI (3), 6,14-di-O-acetylrhodomollein XXI (4), rhodomollein XXII (5), and 2-O-methylrhodomollein XI (6), and two new kalmane-type diterpenoids, rhodomolleins XXIII (7) and XXIV (8), together with seven known compounds, were isolated from the flowers of Rhododendron molle collected in Guangxi Province, China. The absolute configurations of 1 and 3 were defined by single-crystal X-ray diffraction experiments. Compound 1 possesses an unprecedented 1,5-seco-kalmane skeleton presumably derived by cleavage of the C-1鈥揅-5 bond of the kalmane skeleton. Compounds 2鈥?b>4 represent the first examples from a natural source of grayanane-type diterpenoids with a chlorine substituent.