The Lipid Content of Serum Affects the Extraction Efficiencies of Highly Lipophilic Flame Retardants

详细信息    查看全文

• 作者：Enrique Cequier ; Rosa Maria Marcé ; Georg Becher ; Cathrine Thomsen
• 刊名：Environmental Science & Technology Letters
• 出版年：2014
• 出版时间：January 14, 2014
• 年：2014
• 卷：1
• 期：1
• 页码：82-86
• 全文大小：321K

文摘

This work investigates the recoveries from human serum of eight halogenated flame retardants of emerging concern: hexabromobenzene, hexachlorocyclopentenyl-dibromocyclooctane, 1,2-bis(2,4,6-tribromophenoxy)ethane, Dechlorane 602, Dechlorane 603, Dechlorane Plus, decabromodiphenyl ether (BDE-209), and decabromodiphenyl ethane (DBDPE). Extraction efficiencies were assessed using solid phase extraction (Oasis HLB) at two spiking levels with recoveries ranging from 18 to 84% [relative standard deviations (RSDs) of 4鈥?5% (n = 8)]. Recoveries for DBDPE, BDE-209, and Dechlorane Plus averaged 24% (RSD of 18%), 38% (RSD of 20%), and 49% (RSD of 12%), respectively. These low recoveries were negatively associated with the lipid content of the serum, and Pearson correlations ranged from 鈭?.798 to 鈭?.839 (p < 0.002). This fact indicates that interactions between highly lipophilic flame retardants and lipids affect the extraction efficiencies. Therefore, even with thoroughly optimized SPE procedures, studies conducted without a proper internal standard (similar recovery) might result in erroneous calculated concentrations of the highly lipophilic halogenated flame retardants in serum.