A Three-Component Reaction Forming Naphthyridones 鈥?Synthesis of Lophocladine Analogs

详细信息    查看全文

• 作者：Magnus Sellstedt ; Fredrik Almqvist
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：October 7, 2011
• 年：2011
• 卷：13
• 期：19
• 页码：5278-5281
• 全文大小：759K
• 年卷期：v.13,no.19(October 7, 2011)
• ISSN：1523-7052

文摘

A three-component reaction forming dihydro 2,7-naphthyridine-1-ones has been developed. These unstable dihydro intermediates can be either oxidized or reduced to form naphthyridones or tetrahydro naphthyridones, respectively. The reaction tolerates a large variety of aldehydes and amines, and the produced compounds are analogs of the natural product lophocladine A.