A Selective Intramolecular 5-exo-dig or 6-endo-dig Cyclization en Route to 2-Furanone or 2-Pyrone Containing Tricyclic Scaffolds

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• 作者：Christoffer Bengtsson ; Fredrik Almqvist
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：December 2, 2011
• 年：2011
• 卷：76
• 期：23
• 页码：9817-9825
• 全文大小：471K
• 年卷期：v.76,no.23(December 2, 2011)
• ISSN：1520-6904

文摘

Ringfused bicyclic 2-pyridones exhibit interesting biological properties against pili assembly in uropathogenic Escherichia coli (Pinkner, J. S. et al. Proc. Natl. Acad. Sci. U. S. A.2006, 103, 17897鈥?7902; 脜berg, V. et al. Org. Biomol. Chem.2007, 5, 1827鈥?834) as well as curli formation (Cegelski, L. et al. Nat. Chem. Biol.2009, 5, 913鈥?19). In the search for new ring-fused central fragments, highly selective synthetic routes to the 2-furanone or 2-pyrone containing tricyclic scaffolds 1 and 2 have been developed.