Structural Feature of Bent DNA Recognized by HMGB1

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• 作者：Kyoko Furuita ; Shunpei Murata ; Jun Goo Jee ; Satoshi Ichikawa ; Akira Matsuda ; Chojiro Kojima
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：April 20, 2011
• 年：2011
• 卷：133
• 期：15
• 页码：5788-5790
• 全文大小：759K
• 年卷期：v.133,no.15(April 20, 2011)
• ISSN：1520-5126

文摘

High Mobility Group Box 1 (HMGB1) protein, a potential therapeutic target, binds bent DNAs structure-specifically. Here we report on a crucial structural feature of the bent DNA required for strong binding to HMGB1. NMR structures of two bent DNA oligomers, only one of which binds strongly to HMGB1, revealed that the presence of a pocket structure on the minor groove is crucial for strong binding through penetration of a phenylalanine residue.