pH-Operated Mechanized Porous Silicon Nanoparticles

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• 作者：Min Xue ; Xing Zhong ; Zory Shaposhnik ; Yongquan Qu ; Fuyuhiko Tamanoi ; Xiangfeng Duan ; Jeffrey I. Zink
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：June 15, 2011
• 年：2011
• 卷：133
• 期：23
• 页码：8798-8801
• 全文大小：766K
• 年卷期：v.133,no.23(June 15, 2011)
• ISSN：1520-5126

文摘

Porous silicon nanoparticles (PSiNPs) were synthesized by silver-assisted electroless chemical etching of silicon nanowires generated on a silicon wafer. The rod-shaped particles (200鈥?00 nm long and 100鈥?00 nm in diameter) were derivatized with a cyclodextrin-based nanovalve that was closed at the physiological pH of 7.4 but open at pH <6. Release profiles in water and tissue culture media showed that no cargo leaked when the valves were closed and that release occurred immediately after acidification. In vitro studies using human pancreatic carcinoma PANC-1 cells proved that these PSiNPs were endocytosed and carried cargo molecules into the cells and released them in response to lysosomal acidity. These studies show that PSiNPs can serve as an autonomously functioning delivery platform in biological systems and open new possibilities for drug delivery.