Pd(II) Catalyzed Oxidative Degradation of Paracetamol by Chloramine-T in Acidic and Alkaline Media

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• 作者：Ajaya Kumar Singh ; Reena Negi ; Bhawana Jain ; Yokraj Katre ; Surya Prakash Singh ; Virender K. Sharma
• 刊名：Industrial & Engineering Chemistry Research
• 出版年：2011
• 出版时间：July 20, 2011
• 年：2011
• 卷：50
• 期：14
• 页码：8407-8419
• 全文大小：1118K
• 年卷期：v.50,no.14(July 20, 2011)
• ISSN：1520-5045

文摘

Pd(II) catalyzed oxidation of paracetamol (PA) by sodium N-chloro p-toluenesulfonamide (chloramine-T or CAT) was studied in HClO₄ and NaOH solutions at 303 K. The stoichiometry and the oxidation product in both solutions were found to be the same. The determined stoichiometric ratio was 1:2 ([PA]:[CAT]) and quinone oxime was identified as the oxidized product of PA. However, the kinetics patterns in both media were different. In the acidic medium, the rate law was 鈭抎[CAT]/dt = k[CAT][PA]^0.9[Pd(II)]^0.8[H⁺]^鈭?.4 and the rate law was 鈭抎[CAT]/dt = k[CAT][PA]^0.9[Pd(II)] [PTS]^鈭?.4[NaOH]^鈭? in the alkaline medium. p-Toluenesulphonamide (PTS) is the reduced product of CAT. The kinetics of the reaction was studied as a function of temperature, ionic strength, concentration of the salt, concentration of the added reaction product, and dielectric constant of the medium to learn the mechanistic aspects of the reaction. A plausible mechanism is proposed, which is consistent with the kinetics, stoichiometry, and product of the reaction.