Verification of Intramolecular Hybrid/Parallel G-Quadruplex Structure under Physiological Conditions Using Novel Cyanine Dye H-Aggregates: Both in Solution and on Au Film

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• 作者：Qianfan Yang ; Jun-Feng Xiang ; Shu Yang ; Qian Li ; Qiuju Zhou ; Aijiao Guan ; Lin Li ; Yanxia Zhang ; Xiufeng Zhang ; Hong Zhang ; Yalin Tang ; Guangzhi Xu
• 刊名：Analytical Chemistry
• 出版年：2010
• 出版时间：November 15, 2010
• 年：2010
• 卷：82
• 期：22
• 页码：9135-9137
• 全文大小：163K
• 年卷期：v.82,no.22(November 15, 2010)
• ISSN：1520-6882

文摘

The H-aggregates of a novel cyanine dye, 3,3′-di(3-sulfopropyl)-4,5,4′,5′-dibenzo-9-methyl-thiacarbocyanine triethylammonium salt (MTC), have been fabricated to verify hybrid/parallel intramolecular G-quadruplexes from linear duplex and single-strand DNAs under physiological conditions. The recognition is found to be successful both in solution and on Au film. These results have shown MTC H-aggregates, as a supramolecular system, may be used as a potential excellent probe for DNA structure, both in vitro and in vivo.