Benzothiazines in Synthesis. A Formal Total Synthesis of Pseudopteroxazole

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• 作者：Michael Harmata ; Zhengxin Cai ; Yugang Chen
• 刊名：Journal of Organic Chemistry
• 出版年：2009
• 出版时间：August 7, 2009
• 年：2009
• 卷：74
• 期：15
• 页码：5559-5561
• 全文大小：697K
• 年卷期：v.74,no.15(August 7, 2009)
• ISSN：1520-6904

文摘

A formal total synthesis of the antitubercular natural product was accomplished. This work was undertaken to address certain stereochemical problems in our initial synthesis. By using an ester group as a surrogate for a methyl group, we were able to intercept a key intermediate in our first synthesis with better selectivity and greater convergence than had previously been the case.