Wacker-Type Oxidation of Alkynes into 1,2-Diketones Using Molecular Oxygen

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• 作者：Wei Ren ; Yuanzhi Xia ; Shun-Jun Ji ; Yong Zhang ; Xiaobing Wan ; Jing Zhao
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：April 16, 2009
• 年：2009
• 卷：11
• 期：8
• 页码：1841-1844
• 全文大小：129K
• 年卷期：v.11,no.8(April 16, 2009)
• ISSN：1523-7052

文摘

An intriguing new Wacker-type oxidation of alkynes catalyzed by PdBr₂ and CuBr₂ is described, which opens an efficient access to 1,2-diketones using molecular oxygen. Under the optimized conditions, a variety of alkynes, including diarylalkynes, arylalkylalkynes, and dialkylalkynes, were compatible substrates in this transformation. The mechanism of this reaction was preliminarily investigated by control experiments.