Solid-Phase Synthesis and Modification of Thiazole Orange and Its Derivatives and their Spectral Properties

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• 作者：Xuening Fei ; Shaobin Yang ; Baolian Zhang ; Zhijun Liu ; Yingchun Gu
• 刊名：Journal of Combinatorial Chemistry
• 出版年：2007
• 出版时间：November 2007
• 年：2007
• 卷：9
• 期：6
• 页码：943 - 950
• 全文大小：1015K
• 年卷期：v.9,no.6(November 2007)
• ISSN：1520-4774

文摘

A new solid-phase synthesis is shown to be effective in the preparation of cyanine dye Thiazole Orange (TO) and its derivatives, which can be obtained as a traceless cleavage of the Merrifield resin method. The influence of different solvents, substitutional groups, introduced to benzothiazole such as chlorine, methyl, and nitro was extensively studied. The changes of the special characteristic and fluorescence intensity of the TO derivatives were described. The phenomenon of the synergetic effect was also depicted after modifying the TO molecule with chitosan oligosaccharide (CTS) at the end of the alkyl, which can effectively improve the sensitivity of the fluorescent probe.