Rheology of Gastric Mucin Exhibits a pH-Dependent Sol-Gel Transition

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• 作者：Jonathan P. Celli ; Bradley S. Turner ; Nezam H. Afdhal ; Randy H. Ewoldt ; Gareth H. McKinley ; Rama Bansil ; Shyamsunder Erramilli
• 刊名：Biomacromolecules
• 出版年：2007
• 出版时间：May 2007
• 年：2007
• 卷：8
• 期：5
• 页码：1580 - 1586
• 全文大小：124K
• 年卷期：v.8,no.5(May 2007)
• ISSN：1526-4602

文摘

Gastric mucin, a high molecular weight glycoprotein, is responsible for providing the gel-forming properties andprotective function of the gastric mucus layer. Bulk rheology measurements in the linear viscoelastic regimeshow that gastric mucin undergoes a pH-dependent sol-gel transition from a viscoelastic solution at neutral pHto a soft viscoelastic gel in acidic conditions, with the transition occurring near pH 4. In addition to pH-dependentgelation behavior in this system, further rheological studies under nonlinear deformations reveal shear thinningand an apparent yield stress in this material which are also highly influenced by pH.