Honeycomb-Structured Porous Films from Polypyrrole-Containing Block Copolymers Prepared via RAFT Polymerization as a Scaffold for Cell Growth

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• 作者：Danelle Beattie ; Kok Hou Wong ; Charles Williams ; Laura A. Poole-Warren ; Thomas P. Davis ; Christopher Barner-Kowollik ; and Martina H. Stenzel
• 刊名：Biomacromolecules
• 出版年：2006
• 出版时间：April 2006
• 年：2006
• 卷：7
• 期：4
• 页码：1072 - 1082
• 全文大小：1187K
• 年卷期：v.7,no.4(April 2006)
• ISSN：1526-4602

文摘

Honeycomb-structured porous films were prepared using customized amphiphilic block copolymers, synthesizedby RAFT polymerization. Pyrrole was templated along an amphiphilic block copolymer, composed of polystyreneand poly(acrylic acid). Subsequent oxidation of pyrrol to polypyrrole, resulted in the formation of a solublepolypyrrole-containing polymer. Gel permeation chromatography and dynamic light scattering studies confirmedthe solubility of the resulting customized amphiphilic block copolymer, in both water and organic solvent, formingeither micelles or inverse aggregates. Porous films with a hexagonal array of micron-sized pores were generatedwith the polymer, using the breath figures templating technique. The resulting films were found to be non-cytotoxic and hence suitable as scaffolds for tissue engineering. Initial fibroblast cell culture studies on thesescaffolds demonstrated a dependency of cell attachment on the pore size of scaffolds.