Two cholinesterase inhibitors trigger dissimilar effects on behavior and body weight in C57BL/6 mice: The case of chlorpyrifos and rivastigmine

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• 作者：Pia Basaure^a ; ^b ; Fiona Peris-Sampedro^a ; ^b ; Maria Cabré ; ^a ; ^c ; Ingrid Reverte^a ; ^d ; Maria Teresa Colomina^a ; ^b ; ^{mariateresa.colomina@urv.cat}
• 关键词：ACh ; acetylcholine ; AChE ; acetylcholinesterase ; AD ; Alzheimer&rsquo ; s disease ; BM ; Barnes maze ; ChE ; cholinesterase ; CPF ; chlorpyrifos ; FDA ; Food and Drug Administration ; MWM ; Morris water maze ; OF ; open field ; OP ; organophosphate ; RIV ; rivastigmine
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：318
• 期：Complete
• 页码：1-11
• 全文大小：1362 K
• 卷排序：318

文摘

Different doses of rivastigmine induced time-dependent weight increase. CPF and rivastigmine inhibited brain AChE following an isoform-specific pattern. CPF boosted the choice of the random learning strategy at the end of the exposure. CPF affected spatial memory at the end of the exposure period. The low dose of rivastigmine improved memory recall after a washout period.