Bone marrow mesenchymal stem cells decrease CHOP expression and neuronal apoptosis after spinal cord injury

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• 作者：Chuanlong Gu^a ; Heyangzi Li^a ; Chao Wang^a ; Xinghui Song^b ; Yuemin Ding^c ; Mingzhi Zheng^d ; Wei Liu^e ; Yingying Chen^a ; Xiaoming Zhang^a ; Linlin Wang^a ; ^{wanglinin@zju.edu.cn}
• 关键词：BMSCs ; bone marrow mesenchymal stem cells ; BMSCs-CM ; conditioned medium of BMSCs ; CHOP ; C/EBP homology protein ; ER ; endoplasmic reticulum ; H&E ; hematoxylin and eosin ; OGD ; oxygen&ndash ; glucose deprivation ; SCI ; spinal cord injury
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：636
• 期：Complete
• 页码：282-289
• 全文大小：3994 K
• 卷排序：636

文摘

Traumatic injury increased CHOP expression and apoptosis in rat spinal cord. BMSCs transplantation decreased CHOP expression, apoptosis, and increased the locomotor function. Co-culture with BMSCs decreased OGD induced CHOP expression and apoptosis in motor neurons. Co-culture with BMSCs-CM restored the viability of post-OGD motor neurons.