Use of T1-weighted/T2-weighted magnetic resonance ratio to elucidate changes due to amyloid β accumulation in cognitively normal subjects

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• 作者：Fumihiko Yasuno^a ; ^e ; ^{ejm86rp@yahoo.co.jp} ; Hiroaki Kazui^b ; Naomi Morita^c ; Katsufumi Kajimoto^d ; Masafumi Ihara^d ; Akihiko Taguchi^f ; Akihide Yamamoto^e ; Kiwamu Matsuoka^a ; Masato Takahashi^a ; Jyoji Nakagawara^c ; Hidehiro Iida^e ; Toshifumi Kishimoto^a ; Kazuyuki Nagatsuka^d
• 关键词：Aβ ; amyloid beta ; AD ; Alzheimer's disease ; BP ; binding potential ; CSF ; cerebrospinal fluid ; FWHM ; full-width at half maximum ; MRI ; magnetic resonance imaging ; PET ; positron emission tomography ; PiB ; Pittsburgh Compound B ; PiB-BPND ; PiB-BP estimates relative to non-displaceable (ND) binding ; ROC ; receiver operating characteristic ; T1w ; T1-weighted ; T2w ; T2-weighted ; VOI ; volumes of interest
• 刊名：NeuroImage: Clinical
• 出版年：2017
• 出版时间：2017
• 年：2017
• 卷：13
• 期：Complete
• 页码：209-214
• 全文大小：599 K
• 卷排序：13

文摘

We examined the T1w/T2w ratio of MR images in cognitively normal elderly subjects. Aβ deposition was quantified by [11C] PiB-PET binding potential (PiB-BPND). The T1w/T2w ratios were positively correlated with PiB-BPND values. We correctly discriminated subjects with high PIB-BPND using the T1w/T2w ratio. The T1w/T2w ratio from MRI is a potential biological marker of early Aβ deposition.