文摘
Cognitive impairment and dementia are age-related health burden. Neurovascular aging predisposes the brain to reduced blood flow and long-term ischemic injuries, leading to VCID. Diverse pathology underlies VCID, including neuronal loss and white matter injury. Microinfarcts and leukoaraiosis are common. Age-related VCID can be classified into ischemic, hemorrhagic and post-stroke subtypes.