2-(2-Phenylethyl)chromones from Endophytic Fungal Strain Botryosphaeria rhodina A13 from Aquilaria sinensis

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• 作者：Yao Zhang^&dagger ; ; Hong-xin Liu^&dagger ; ; Wen-shan Li ; Mei-hua Tao ; Qing-ling Pan ; Zhang-hua Sun ; Wei Ye ; Hao-hua Li ; Wei-min Zhang ; ^{wmzhang@gdim.cn}
• 关键词：agarwood ; Aquilaria sinensis ; Botryosphaeria rhodina A13 ; 2-(2-phenylethyl) chromones ; solid culture
• 刊名：Chinese Herbal Medicines
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：9
• 期：1
• 页码：58-62
• 全文大小：662 K
• 卷排序：9

文摘

To study the characteristic 2-(2-phenylethyl)chromone components of endophytic fungal strain of Aquilaria sinensis by solid culture.MethodsThe compounds were isolated by various chromatographic methods such as silica gel, reverse-phase silica gel, Sephadex-LH20 column chromatography as well as crystallization.ResultsSeven 2-(2-phenylethyl)chromone analogues were isolated from the solid culture of Botryosphaeria rhodina A13. Their structures were established by spectral data as well as physicochemical properties, and identified as 6-hydroxy-7-methoxy-2-(2-phenylethyl)chromone (1), 6,7-dimethoxy-2-(2-phenylethyl) chromone (2), (5S,6R,7S,8R)-2-(2-phenylethyl)-5,6,7,8-tetrahydrchromone (3), 6-hydroxy-2-(2-phenylethyl)chromone (4), 4′-hydroxy-2-(2-phenylethyl)chromone (5), 6-methoxy-2-phenethyl-4H-chromen-4-one (6), and 6-methoxy-2-(4′-methoxy-phenethyl)-4H-chromen-4-one (7).ConclusionAll of the compounds are isolated for the first time from the genus Botryosphaeria. This research opens up a new vista to produce the characteristic components of agarwood by endophytic fungi.