Re-emergence of amantadine-resistant variants among highly pathogenic avian influenza H5N1 viruses in Egypt

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• 作者：Rabeh El-Shesheny^a ; ^b ; Ola Bagato^a ; Ahmed Kandeil^a ; Ahmed Mostafa^a ; Sara H. Mahmoud^a ; Hamdi M. Hassanneen^c ; Richard J. Webby^b ; Mohamed A. Ali^a ; ^{mohamedahmedali2004@yahoo.com} ; Ghazi Kayali^d ; ^e ; ^{ghazi@human-link.org}
• 关键词：H5N1 viruses ; Amantadine-resistant ; Egypt
• 刊名：Infection, Genetics and Evolution
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：46
• 期：Complete
• 页码：102-109
• 全文大小：635 K
• 卷排序：46

文摘

Selection pressure was identified in the transmembrane domain of M2 gene. Amantadine-resistant variants were not circulating between 2012 and 2014. Re-emergence of amantadine-resistant HPAI H5N1 viruses was detected in 2015.