Dengue virus induces mitochondrial elongation through impairment of Drp1-triggered mitochondrial fission

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• 作者：Vincent Barbier ; Diane Lang ; Sierra Valois ; Alan L. Rothman ; Carey L. Medin ; ^{cmedin.uri@gmail.com}
• 关键词：Dengue virus ; Drp1 ; Mitochondria ; Fusion ; Fission ; Live-cell imaging ; Dendritic cells
• 刊名：Virology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：500
• 期：Complete
• 页码：149-160
• 全文大小：1693 K
• 卷排序：500

文摘

Mitochondrial length and respiration are increased during DENV infection. DENV inhibits Drp1-triggered mitochondrial fission. DENV titers are reduced by mitochondrial fragmentation, Drp1 WT and S616D expression. Viral proteins NS4b and NS3 are associated with subcellular fractions of mitochondria.