Effects of gene carrier polyethyleneimines on the structure and binding capability of bovine serum albumin

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• 作者：Zhiyong Guo ; Zhijie Kong ; Yanshan Wei ; Hua Li ; Yajing Wang ; Aimin Huang ; Lin Ma ; ^{malinzju@163.com} ; ^{malin_gxu@163.com}
• 关键词：Polyethyleneimine ; Bovine serum albumin ; Conformation ; Interaction ; Binding
• 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：173
• 期：Complete
• 页码：783-791
• 全文大小：850 K
• 卷排序：173

文摘

PEI bound to BSA and located at the surface of the protein. PEI induced an alteration of secondary and tertiary structure of BSA. PEI greatly reduced the binding efficacy of BSA to small compounds. The polymer size played an important role in PEI-BSA interaction.