MicroRNA-24 inhibits osteosarcoma cell proliferation both in vitro and in vivo by targeting LPAAT¦Â

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• 作者：Lei Song^a ; ¹ ; Jie Yang^b ; ¹ ; Ping Duan^c ; Jianzhong Xu^a ; Xiangdong Luo^d ; Fei Luo^a ; Zehua Zhang^a ; Tianyong Hou^a ; Bing Liu^e ; ^{liubing52000@163.com} ; Qiang Zhou^a ; ^{zqthl@yahoo.com.cn}
• 关键词：Lysophosphatidic acid acyltransferase ¦Â ; LPAAT¦Â ; Osteosarcoma ; miR-24
• 刊名：Archives of Biochemistry and Biophysics
• 出版年：2013
• 出版时间：15 July, 2013
• 年：2013
• 卷：535
• 期：2
• 页码：128-135
• 全文大小：1904 K

文摘

Lysophosphatidic Acid Acyltransferase ¦Â (LPAAT¦Â) may be critically involved in osteosarcoma cell proliferation. However, the comprehensive mechanisms responsible for regulation of LPAAT¦Â in osteosarcoma cells remain unclear. This study found that enhanced LPAAT¦Â expression was correlated with osteosarcoma cell proliferation. MiR-24, targeted to LPAAT¦Â, was down-regulated in osteosarcoma cells. Overexpression of miR-24 down-regulated LPAAT¦Â expression in osteosarcoma cells. Specifically, overexpression of miR-24 inhibited osteosarcoma cell proliferation, however, such effect was blocked when LPAAT¦Â activity was inhibited. In conclusion, our study indicates that miR-24 is reduced in osteosarcoma cells, contributing to up-regulation of LPAAT¦Â and resultant osteosarcoma cell proliferation.