Synthesis, biological evaluation, and molecular dynamics (MD) simulation studies of three novel F-18 labeled and focal adhesion kinase (FAK) targeted 5-bromo pyrimidines as radiotracers for tumor

详细信息    查看全文

• 作者：Yu Fang ; Dawei Wang ; Xingyu Xu ; Jianping Liu ; Aiqin Wu ; Xiang Li ; Qianqian Xue ; Huan Wang ; Hang Wang ; Huabei Zhang ; ^{hbzhang@bnu.edu.cn}
• 关键词：F-18 labeled ; Focal adhesion kinase (FAK) ; Radiotracers ; Tumor imaging ; Molecular dynamics (MD) simulation
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：493-508
• 全文大小：2402 K
• 卷排序：127

文摘

This was the first attempt to develop the FAK targeted tumor diagnostic imaging agents on the radiopharmaceutical level. Coronal micro-PET/CT images of a mouse bearing S180 tumor confirmed that [18F]2 could be accumulated in tumor. The results of the molecular dynamics simulations consists with the changing trends of the interaction between F-19 standards and the FAK.