Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice

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• 作者：Christoph D. Rau¹ ; ³ ; ⁶ ; Milagros C. Romay¹ ; ⁶ ; Mary Tuteryan¹ ; Jessica J.-C. Wang² ; Marc Santolini⁴ ; Shuxun Ren³ ; Alain Karma⁴ ; James N. Weiss² ; Yibin Wang³ ; Aldons J. Lusis¹ ; ² ; ⁵ ; ⁷ ; ^{jlusis@mednet.ucla.edu}
• 关键词：gene network ; causal modeling ; siRNA mediated knockdown ; MICA ; ventricular myocytes
• 刊名：Cell Systems
• 出版年：2017
• 出版时间：25 January 2017
• 年：2017
• 卷：4
• 期：1
• 页码：121-128.e4
• 全文大小：2823 K
• 卷排序：4

文摘

Co-expression networks were created from heart transcriptomes of 100 mouse strains A module was identified that strongly correlated to heart-failure-related traits The NEO algorithm identified Adamts2 as an important driver of the module In vitro studies demonstrated that Adamts2 is a regulator of cardiac hypertrophy