Sestrin2 induced by hypoxia inducible factor1 alpha protects the blood-brain barrier via inhibiting VEGF after severe hypoxic-ischemic injury in neonatal rats
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- 作者：Xudan Shia ; b ; 1 ; Desislava Met Doychevab ; 1 ; Liang Xub ; Jiping Tangb ; Min Yana ; zryanmin@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; John H. Zhangb ; johnzhang3910@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hi 95 ; Hypoxia inducible factor1 ; Brain edema ; Neonatal hypoxic-ischemic encephalopathy
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：111-121
- 全文大小：2399 K
文摘
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Sestrin2 expression levels are dependent on the severity of neonatal brain injury.
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Moderate and severe neonatal brain injuries induce sestrin2 expression differently.
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Sestrin2 is induced by HIF1α upon severe but not moderate neonatal brain injury.
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Sestrin2 has a protective effect on BBB after neonatal brain injury.
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HIF1α exerts biphasic effects in moderate and severe neonatal brain models.
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