Gastrin-releasing peptide facilitates glutamatergic transmission in the hippocampus and effectively prevents vascular dementia induced cognitive and synaptic plasticity deficits
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- 作者：Jiajia Yanga ; 1 ; Yang Yaob ; 1 ; Ling Wanga ; Chunxiao Yangc ; Faqi Wanga ; Jie Guob ; Zhiyun Wangb ; Zhuo Yangc ; zhuoyang@nankai.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Dong Minga ; richardming@tju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Gastrin-releasing peptide ; Synaptic transmission ; Cognitive function ; Plasticity ; Synaptic proteins
- 刊名：Experimental Neurology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：287
- 期：part_P1
- 页码：75-83
- 全文大小：1315 K
文摘
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Acute and chronic effects of exogenous GRP were examined on hippocampal neurons.
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GRP presynaptically enhanced the excitatory transmission in hippocampal neurons.
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GRP and NMB improved spatial cognitive ability and synaptic plasticity in VD rats.
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GRP and NMB elevated the expression of synaptic proteins, SYP and CaMKII in VD rats.
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