Femoral bone structure in Otsuka Long-Evans Tokushima Fatty rats

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• 作者：Akira Minematsu^a ; ^{a.minematsu@kio.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Tomoko Hanaoka^b ; Yoshihiro Takada^b ; ^c ; Shunji Okuda^d ; Hidetaka Imagita^a ; Susumu Sakata^e
• 关键词：Cortical bone geometry ; Micro-CT ; Otsuka Long-Evans Tokushima Fatty (OLETF) rats ; Trabecular bone microstructure
• 刊名：Osteoporosis and Sarcopenia
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：2
• 期：1
• 页码：25-29
• 全文大小：378 K

文摘

Type 2 diabetes mellitus (T2DM) increases fracture risk despite normal to high levels of bone mineral density. Bone quality is known to affect bone fragility in T2DM. The aim of this study was to clarify the trabecular bone microstructure and cortical bone geometry of the femur in T2DM model rats.

Methods

Five-week-old Otsuka Long-Evans Tokushima Fatty (OLETF; n = 5) and Long-Evans Tokushima Otsuka (LETO; n = 5) rats were used. At the age of 18 months, femurs were scanned with micro-computed tomography, and trabecular bone microstructure and cortical bone geometry were analyzed.

Results

Trabecular bone microstructure and cortical bone geometry deteriorated in the femur in OLETF rats. Compared with in LETO rats, in OLETF rats, bone volume fraction, trabecular number and connectivity density decreased, and trabecular space significantly increased. Moreover, in OLETF rats, cortical bone volume and section area decreased, and medullary volume significantly increased.

Conclusions

Long-term T2DM leaded to deterioration in trabecular and cortical bone structure. Therefore, OLETF rats may serve as a useful animal model for investigating the relationship between T2DM and bone quality.