The pro-inflammatory and anti-inflammatory cytokine profile in peripheral blood of women with recurrent implantation failure

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• 作者：Pei-Yan Liang^a ; ^b ; ^cAuthor Vitae ; Liang-Hui Diao^b ; ^c ; Chun-Yu Huang^b ; ^c ; Ruo-Chun Lian^b ; ^c ; Xian Chen^b ; ^c ; Guan-Gui Li^b ; ^c ; Jin Zhao^a ; Yu-Ye Li^b ; ^c ; Xue-bing He^b ; ^c ; Yong Zeng^b ; ^c ; ^{zengyong1966@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：anti-inflammatory cytokines ; IVF/ICSI&ndash ; ET ; pro-inflammatory cytokines ; recurrent implantation failure
• 刊名：Reproductive BioMedicine Online
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：31
• 期：6
• 页码：823-826
• 全文大小：400 K

文摘

Limited information is available on the balance state of pro- and anti-inflammatory cytokines in patients with recurrent implantation failure (RIF). This study assessed the pro- and anti-inflammatory cytokines in plasma of 34 patients with RIF, compared with those of 25 women with a successful pregnancy in the first IVF/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI–ET) cycle. The IFN-γ, IL-1β, IL-6 and IL-4 concentrations were higher, whereas the TGF-β1 concentration was lower in the RIF group compared with the control group. Furthermore, the ratios of pro-inflammatory and anti-inflammatory cytokines IFN-γ/IL-4, IFN-γ/IL-10, IFN-γ/TGF-β1, IL-6/IL-10, IL-6/TGF-β1, IL-1β/TGF-β1 and TNF-α/TGF-β1 were higher in the RIF group (all P < 0.01). The results suggested a shift toward a pro-inflammatory state in peripheral blood of the patients with RIF.