Benchmarking quantitative label-free LC-MS data processing workflows using a complex spiked proteomic standard dataset

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Benchmarking quantitative label-free LC-MS data processing workflows using a complex spiked proteomic standard dataset

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作者：Claire Ramus^a ; ^d ; ^e ; ^f ; ¹ ; ^{claire.ramus@cea.fr" class="auth_mail" title="E-mail the corresponding author} ; Agnè ; s Hovasse^a ; ^g ; ¹ ; ^{ahovasse@unistra.fr" class="auth_mail" title="E-mail the corresponding author} ; Marlè ; ne Marcellin^a ; ^b ; ^c ; ¹ ; ^{marlene.marcellin@ipbs.fr" class="auth_mail" title="E-mail the corresponding author} ; Anne-Marie Hesse^a ; ^d ; ^e ; ^f ; ¹ ; ^{anne-marie.hesse@cea.fr" class="auth_mail" title="E-mail the corresponding author} ; Emmanuelle Mouton-Barbosa^a ; ^b ; ^c ; ^{emmanuelle.mouton@ipbs.fr" class="auth_mail" title="E-mail the corresponding author} ; David Bouyssié ; ^a ; ^b ; ^c ; ^{bouyssie@ipbs.fr" class="auth_mail" title="E-mail the corresponding author} ; Sebastian Vaca^a ; ^g ; ^{sebastian.vaca@etu.unistra.fr" class="auth_mail" title="E-mail the corresponding author} ; Christine Carapito^a ; ^g ; ^{ccarapito@unistra.fr" class="auth_mail" title="E-mail the corresponding author} ; Karima Chaoui^a ; ^b ; ^c ; ^{karima.chaoui@ipbs.fr" class="auth_mail" title="E-mail the corresponding author} ; Christophe Bruley^a ; ^d ; ^e ; ^f ; ^{christophe.bruley@cea.fr" class="auth_mail" title="E-mail the corresponding author} ; Jé ; rô ; me Garin^a ; ^d ; ^e ; ^f ; ^{jerome.garin@cea.fr" class="auth_mail" title="E-mail the corresponding author} ; Sarah Cianfé ; rani^a ; ^g ; ^{sarah.cianferani@unistra.fr" class="auth_mail" title="E-mail the corresponding author} ; Myriam Ferro^a ; ^d ; ^e ; ^f ; ^{myriam.ferro@cea.fr" class="auth_mail" title="E-mail the corresponding author} ; Alain Van Dorssaeler^a ; ^g ; ^{vandors@unistra.fr" class="auth_mail" title="E-mail the corresponding author} ; Odile Burlet-Schiltz^a ; ^b ; ^c ; ^{schiltz@ipbs.fr" class="auth_mail" title="E-mail the corresponding author} ; Christine Schaeffer^a ; ^g ; ^{christine.schaeffer@unistra.fr" class="auth_mail" title="E-mail the corresponding author} ; Yohann Couté ; ^a ; ^d ; ^e ; ^f ; ^{yohann.coute@cea.fr" class="auth_mail" title="E-mail the corresponding author} ; Anne Gonzalez de Peredo^a ; ^b ; ^c ; ^{gonzalez@ipbs.fr" class="auth_mail" title="E-mail the corresponding author}
关键词：Proteomic standard ; NanoLC&ndash ; MS/MS ; Label-free quantification ; Computational proteomics ; Spectral counting ; MS signal analysis
刊名：Journal of Proteomics
出版年：2016
出版时间：30 January 2016
年：2016
卷：132
期：Complete
页码：51-62
全文大小：1414 K

文摘

class="label">•: We provide a proteomic dataset generated from samples spiked with different amounts of recombinant proteins
class="label">•: We benchmarked several label-free quantitative workflows based either on spectral counting or on peptide ions MS intensity
class="label">•: We evaluated their performances for detection of variant proteins with different abundance and fold change values

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