Neuroprotective effect of Valeriana wallichii rhizome extract against the neurotoxin MPTP in C57BL/6 mice
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- 作者：Subhashree Sridharana ; Kumaravel Mohankumara ; Syam Praveen Kumar Jeepipallia ; Divya Sankaramourthyb ; Larance Ronsardc ; Kavimani Subramanianb ; Manivasagam Thamilarasand ; Kumar Rajae ; Varshney Khub Chandrae ; Sudha Rani Sadrasa ; dr.ssrlab@gmail.com" class="auth_mail" title="E-mail the corresponding author ; sadrassudha@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Parkinson's disease ; MPTP ; Valeriana wallichii D.C. ; Dopamine ; Tyrosine hydroxylase ; Antioxidants
- 刊名：Neurotoxicology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：51
- 期：Complete
- 页码：172-183
- 全文大小：3953 K
文摘
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The V. wallichii rhizome extract (VWE), was tested for anti-parkinsonian activity.
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VWE exhibited potential improvement in the behavioural scores of PD mice.
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VWE improved the glutathione and antioxidant system in PD mice.
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VWE also halted the pathological changes and inflammation in PD mice.
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