The history of Huanghua depression subsidence was analyzed by explained the structural characteristics of 22 seismic profiles of Huanghua depression in Bohai Bay Basin. Based on the subsidence history of nine main sags in the Huanghua depression, it could be found that the tectonic subsidence of Huanghua depression had an obviously space-time discrepancy among the Cenozoic.The results show that the Huanghua depression underwent the episodic subsidence in the time, including the rifting episodic Ⅰ is the sedimentary period of the Kongdian Formation, the rifting episodic Ⅱ is the sedimentary period of the 3th member of the Shahejie Formation, the rifting episodic Ⅲ are the sedimentary period of the 1st and 2nd member of the Shahejie Formation and the Dongying Formation, thermal subsidence episodic are the sedimentary period of the Guangtao Formation and the lower submember of the Minghuazhen Formation, accelerated thermal subsidence episodic are the sedimentary period of the upper submember of the Minghuazhen Formation and the Quaternary.