In this paper, the authors analyzed the regional tectonics uplift quantitatively and the thermal history inversion of in the southeast Tibet Plateau and Sanjiang area by 8 apatite and zircon fission track samples. The research indicates that the southeast Tibet Plateau experiences two tectonics uplift stages. The tectonics uplift is at 50 Ma and 6～5 Ma separately. Its characteristic is of slow uplift in the early stage, and fast uplift rate at 0.5 mm/a during the later stage. The tectonics uplift in Chuxiong Basin of Sanjiang area is affected by the middle fault and basement uplifts. The vertical movements are shown opposite trend in the Eastern and Western sub depression separately during 120～60 Ma.