Based on the structure interpretation and the analysis of regional tectonic setting controlling on oil, it indicates that multi-cycle tectonic movement and migration of palaeo-uplifts had occurred in Tarim Basin. It includes six stages of evolution: the commence of basement lift in the Precambrian, the formation before the end of Early Ordovician, completion before the end of Ordovician, modification during Silurian-Devonian, local regulation during the end of Permian, tectonic station during Mesozoic. The polycyclic tectonic movements together with three stages of hydrocarbon migration and accumulations, resulted in the vertical overlap of the producing layer, reservoir rock, multi-phase and multi-type of oil reservoir, and then formed a complex petroleum accumulation zone in the palaeo-uplifts.