The Kangdian axis is one of important polymetallic mineralization belts in China, but geological investigation for uranium ores has not made breakthrough progress. This paper makes an approach to the characteristics and genetic model for uranium mineralization related to the unconformity between Mesoproterozoic and Neoproterozoic in the Jianchuan-Jianshui area, south section of the Kangdian axis. The study indicates fracture-alteration zones cutting the unconformity are of U-searching promising.