Tonglüshan Fe-Cu(Au) deposit is one of the largest skarn deposits in middle-lower Yangtze River metallogenic belt, which is associated with the Early Cretaceous Yangxin quartz diorite stock. Granitic pegmatites are well developed in the southeast mining area, emplaced in the Yangxin quartz diorite pluton and cut by garnet-diopside skarn. Abundance of melt and fluid inclusions in quartz minerals from the granitic pegmatites demonstrates that the pegmatite formed from melt and fluid coexisting system. The study provides a better understanding of the formation of pegmatites, exsolution of ore fluids from evolving magmas, and hydrothermal mineralization.