The reconstruction of the eastern Tethys, i.e., Qinghai-Tibetan Plateau Tethys, has been practicing. The main itinerary is summarized as: firstly, recovering the original locations of terrenes or plates in Qinghai-Tibetan Plateau by paleomagnetism with combination of the paleotectonic and paleontology; secondly, confining the border and scale of terrenes and basins on deep geophysics, surface geology and biogeography; thirdly, restoring original basins by recovering techniques of deformed-shorten strata and balanced cross-section; fourthly, composing maps of biogeography and lithofacies paleogeography on the basis of the identification and classification of sedimentary and biological facieses; and finally, exploring the prosperous hydrocarbons on paleoceanography, paleoclimate and paleogeography in Tibetan Tethys.