长链非编码RNA的微RNA海绵作用与呼吸系统疾病
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摘要
长链非编码RNA(long non-coding RNAs,lncRNAs)是一类由长度大于200个核苷酸组成的长链非编码序列。lncRNAs具有较长的序列,使得lncRNAs具有复杂的二级及三级结构,这也是lncRNAs结合DNA、RNA和蛋白质及其行使复杂功能的结构基础。MicroRNA(miRNAs)是长度在19到25个核苷酸之间的非编码单链RNA分子,是目前研究最多的小分子非编码RNA。而lncRNAs通过结合或者螯合miRNA来调节miRNA丰度,发挥lncRNA的"海绵"作用,从而调控一系列的病理生理过程。lncRNAs及miRNA在呼吸系统疾病的发生、发展、治疗和预后起重要作用。本文就lncRNAs及其"海绵"作用对呼吸系统疾病的影响及可能的机制进行综述。
Long non-coding RNAs(lncRNAs) are a class of long non-coding sequences composed of more than 200 nucleotides. Because of its longer sequences,lncRNAs have a complex secondary and tertiary structure,which is the structural basis for lncRNAs to bind DNA,RNA,and proteins and perform complex functions. MicroRNAs(miRNAs) are a class of small non-coding RNAs(19-25 nucleotides),which is the most studied type of small non-coding RNAs. lncRNA can act as a "sponge"by combining with miRNAs to regulate a series of pathophysiological processes. lncRNAs and miRNAs play an important role in the occurrence,development,treatment and prognosis of respiratory diseases.This article reviews the effects and mechanisms of lncRNA acting as sponges on respiratory diseases.
Long non-coding RNAs(lncRNAs) are a class of long non-coding sequences composed of more than 200 nucleotides. Because of its longer sequences,lncRNAs have a complex secondary and tertiary structure,which is the structural basis for lncRNAs to bind DNA,RNA,and proteins and perform complex functions. MicroRNAs(miRNAs) are a class of small non-coding RNAs(19-25 nucleotides),which is the most studied type of small non-coding RNAs. lncRNA can act as a "sponge"by combining with miRNAs to regulate a series of pathophysiological processes. lncRNAs and miRNAs play an important role in the occurrence,development,treatment and prognosis of respiratory diseases.This article reviews the effects and mechanisms of lncRNA acting as sponges on respiratory diseases.
引文
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[26]Wang S Y,Fan X L,Yu Q N,et al.The lncRNAs involved in mouse airway allergic inflammation following induced pluripotent stem cell-mesenchymal stem cell treatment[J].Stem Cell Res Ther,2017,8(1):2
[27]Bi H,Zhou J,Wu D,et al.Microarray analysis of long noncoding RNAs in COPD lung tissue[J].Inflamm Res,2015,64(2):119-126
[28]Chen X,Lu X,Chen J,et al.Association of nsv823469 copy number loss with decreased risk of chronic obstructive pulmonary disease and pulmonary function in Chinese[J].Sci Rep,2017,7:40060
[29]Tang W,Shen Z,Guo J,et al.Screening of long non-coding RNA and TUG1 inhibits proliferation with TGF-beta;induction in patients with COPD[J].Int J Chron Obstruct Pulmon Dis,2016,11:2951-2964
[30]Chang HY,Chen YC,Lin JG,et al.Asatone prevents acute lung injury by reducing expressions of NF-κB,MAPK and inflammatory cytokines[J].Am J Chin Med,2018,46(3):651-671
[31]Zhang D,Lee H,Haspel J A,et al.Long noncoding RNAFOXD3-AS1 regulates oxidative stress-induced apoptosis via sponging microRNA-150[J].FASEB J,2017,31(10):4472-4481
[32]Wu L,Sun L,Hua Y,et al.Overexpression of long non-coding RNA H19 protects lung fibroblasts from LPS-induced injury by targeting miR-181a and Runx2 via activation of Notch and JNKpathways[J].J Cell Biochem,2018,doi:10.1002/jcb.26660
[2]Geisler S,Coller J.RNA in unexpected places:long non-coding RNA functions in diverse cellular contexts[J].Nat Rev Mol Cell Biol,2013,14(11):699-712
[3]Plosky B S.An ultraconserved lnc to miRNA processing[J].Mol Cell,2014,55(1):3-4
[4]Hansen T B,Jensen T I,Clausen B H,et al.Natural RNAcircles function as efficient microRNA sponges[J].Nature,2013,495(7441):384-388
[5]Del Vescovo V,Denti M A.microRNA and lung cancer[J].Adv Exp Med Biol,2015,889:153-177
[6]Friedman R C,Farh K K,Burge C B,et al.Most mammalian mRNAs are conserved targets of microRNAs[J].Genome Res,2009,19(1):92-105
[7]Gaiti F,Calcino A D,Tanurdzic M,et al.Origin and evolution of the metazoan non-coding regulatory genome[J].Dev Biol,2017,427(2):193-202
[8]Singh A K,Aryal B,Zhang X,et al.Posttranscriptional regulation of lipid metabolism by non-coding RNAs and RNAbinding proteins[J].Semin Cell Dev Biol,2018,81:129-140
[9]Duval M,Cossart P,Lebreton A.Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk[J].Semin Cell Dev Biol,2017,65:11-19
[10]隗思媛,孟畅,李淑艳.长链非编码RNA的功能与疾病治疗的潜力[J].中国生物化学与分子生物学报(Kui S Y,Meng C,Li S Y.Function of long non-coding RNA and its potentials for clinical therapy[J].Chin J Biochem Mol Biol),2018,34(2):129-136
[11]Devaux Y,Zangrando J,Schroen B,et al.Long noncoding RNAs in cardiac development and ageing[J].Nat Rev Cardiol,2015,12(7):415-425
[12]Li L J,Leng R X,Fan Y G,et al.Translation of noncoding RNAs:Focus on lncRNAs,pri-miRNAs,and circRNAs[J].Exp Cell Res,2017,361(1):1-8
[13]Li J,Tian H,Yang J,et al.Long noncoding RNAs regulate cell growth,proliferation,and apoptosis[J].DNA Cell Biol,2016,35(9):459-470
[14]Salmena L,Poliseno L,Tay Y,et al.A ceRNA hypothesis:the Rosetta Stone of a hidden RNA language?[J].Cell,2011,146(3):353-358
[15]Zhang Z K,Li J,Guan D,et al.A newly identified lncRNAMAR1 acts as a miR-487b sponge to promote skeletal muscle differentiation and regeneration[J].J Cachexia Sarcopenia Muscle,2018,9(3):613-626
[16]Liu X H,Sun M,Nie F Q,et al.Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer[J].Mol Cancer,2014,13:92
[17]Fu Y,Li C,Luo Y,et al.Silencing of long non-coding RNAMIAT sensitizes lung cancer cells to Gefitinib by epigenetically regulating miR-34a[J].Front Pharmacol,2018,9:82
[18]Terashima M,Tange S,Ishimura A,et al.MEG3 long noncoding RNA contributes to the epigenetic regulation of epithelialmesenchymal transition in lung cancer cell lines[J].J Biol Chem,2017,292(1):82-99
[19]Lu Q,Shan S,Li Y,et al.Long noncoding RNASNHG1promotes non-small cell lung cancer progression by up-regulating MTDH via sponging miR-145-5p[J].FASEB J,2018,32(7):3957-3967
[20]Tang Y,He R,An J,et al.The effect of H19-miR-29b interaction on bleomycin-induced mouse model of idiopathic pulmonary fibrosis[J].Biochem Biophys Res Commun,2016,479(3):417-423
[21]Liu H,Wang B,Zhang J,et al.A novel lnc-PCF promotes the proliferation of TGF-beta1-activated epithelial cells by targeting miR-344a-5p to regulate map3k11 in pulmonary fibrosis[J].Cell Death Dis,2017,8(10):e3137
[22]Wu Q,Han L,Yan W,et al.miR-489 inhibits silica-induced pulmonary fibrosis by targeting My D88 and Smad3 and is negatively regulated by lncRNA CHRF[J].Sci Rep,2016,6:30921
[23]Perry M M,Durham A L,Austin P J,et al.BET bromodomains regulate transforming growth factor-β-induced proliferation and cytokine release in asthmatic airway smooth muscle[J].J Biol Chem,2015,290(14):9111-9121
[24]Austin P J,Tsitsiou E,Boardman C,et al.Transcriptional profiling identifies the long noncoding RNA plasmacytoma variant translocation(PVT1)as a novel regulator of the asthmatic phenotype in human airway smooth muscle[J].J Allergy Clin Immunol,2017,139(3):780-789
[25]Zhang X Y,Tang X Y,Ma L J,et al.Schisandrin B downregulated lncRNA BCYRN1 expression of airway smooth muscle cells by improving miR-150 expression to inhibit the proliferation and migration of ASMC in asthmatic rats[J].Cell Prolif,2017,50(6).doi:10.1111/cpr.12382
[26]Wang S Y,Fan X L,Yu Q N,et al.The lncRNAs involved in mouse airway allergic inflammation following induced pluripotent stem cell-mesenchymal stem cell treatment[J].Stem Cell Res Ther,2017,8(1):2
[27]Bi H,Zhou J,Wu D,et al.Microarray analysis of long noncoding RNAs in COPD lung tissue[J].Inflamm Res,2015,64(2):119-126
[28]Chen X,Lu X,Chen J,et al.Association of nsv823469 copy number loss with decreased risk of chronic obstructive pulmonary disease and pulmonary function in Chinese[J].Sci Rep,2017,7:40060
[29]Tang W,Shen Z,Guo J,et al.Screening of long non-coding RNA and TUG1 inhibits proliferation with TGF-beta;induction in patients with COPD[J].Int J Chron Obstruct Pulmon Dis,2016,11:2951-2964
[30]Chang HY,Chen YC,Lin JG,et al.Asatone prevents acute lung injury by reducing expressions of NF-κB,MAPK and inflammatory cytokines[J].Am J Chin Med,2018,46(3):651-671
[31]Zhang D,Lee H,Haspel J A,et al.Long noncoding RNAFOXD3-AS1 regulates oxidative stress-induced apoptosis via sponging microRNA-150[J].FASEB J,2017,31(10):4472-4481
[32]Wu L,Sun L,Hua Y,et al.Overexpression of long non-coding RNA H19 protects lung fibroblasts from LPS-induced injury by targeting miR-181a and Runx2 via activation of Notch and JNKpathways[J].J Cell Biochem,2018,doi:10.1002/jcb.26660
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