降压药物对未绝经女性高血压患者性功能影响
摘要
目的:观察临床常见3类降压药物对未绝经女性高血压患者性功能的影响。方法:选取2017年12月至2018年6月在荆州市第一人民医院、监利县中医院及监利县第二人民医院(门诊或住院部)初次就诊符合纳入标准的高血压妇女患者共124例(计入统计分析104例),随机分为钙通道阻滞剂(calcium channel blockers,CCB)组(42例)、血管紧张素转换酶抑制剂(angiotensin converting enzyme inhibitor,ACEI)组(41例)及血管紧张素受体拮抗剂(Angiotensin Receptor Blockers,ARB)组(41例)。收集治疗前后的血压及女性性功能指数量表(female sexual function index,FSFI)得分。结果:经12周及24周治疗,3组血压均较治疗前明显降低(P<0.05),用药后组间收缩压及舒张压比较差异无统计学意义(P>0.05)。经过12周治疗后,各个组别治疗前后的性功能差异均无统计学意义(P>0.05);经过24周治疗后,CCB组治疗前后性功能差异无统计学意义(P>0.05),但ACEI组及ARB组均在性欲及性唤起能力方面有改善,差异有统计学意义(P<0.05)。结论:CCB对未绝经女性高血压患者性功能无影响,ACEI及ARB可改善女性性功能。
引文
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[7]Imprialos K P,Stavropoulos K,Doumas M,et al.Sexual dysfunction,cardiovascular risk and effects of pharmacotherapy[J].Curr Vasc Pharmacol,2018,16(2):130~142.
[8]孙嫣.厄贝沙坦和琥珀酸美托洛尔对女性高血压患者的性功能和性激素影响的前瞻性研究[J].中国性科学,2013,22(12):35~37.
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[12]Ma R,Yu J,Xu D,et al.Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension[J].J Hypertens,2012,30(1):210~216.
[2]李青,远丽,徐青.女性性功能指数调查量表FSFI的使用现状与评分方法[C].北京:国际康复论坛.2014.
[3]赵锋,马瑞新,林欣,等.高血压患者性功能状况[J].中华高血压杂志,2013,21(10):938~943.
[4]De F P,Mainini G,Messalli E M,et al.Arterial hypertension and female sexual dysfunction in postmenopausal women[J].Clin Exp Obstet Gynecol,2013,40(1):58~60.
[5]Latif R A,Muhamad R,Ann A Y,et al.Duration of hypertension and antihypertensive agents in correlation with the phases of female sexual response cycle.[J].Compr Psychiatry,2014,55(Suppl1):S7~S12.
[6]Steinke E E,Mosack V,Hill T J.Change in sexual activity after a cardiac event:the role of medications,comorbidity,and psychosocial factors[J].Appl Nurs Res,2015,28(3):244~250.
[7]Imprialos K P,Stavropoulos K,Doumas M,et al.Sexual dysfunction,cardiovascular risk and effects of pharmacotherapy[J].Curr Vasc Pharmacol,2018,16(2):130~142.
[8]孙嫣.厄贝沙坦和琥珀酸美托洛尔对女性高血压患者的性功能和性激素影响的前瞻性研究[J].中国性科学,2013,22(12):35~37.
[9]Spatz E S,Canavan M E,Desai M M,et al.Sexual activity and function among middle-aged and older men and women with hypertension[J].J Hypertens,2013,31(6):1096~1105.
[10]Thomas H N,Evans G W,Berlowitz D R,et al.Antihypertensive medications and sexual function in women:baseline data from the SBP intervention trial(SPRINT)[J].J Hypertens,2016,34(6):1224~1231.
[11]Okeahialam B N.Valsartan,an angiotensin receptor blocker treats sexual dysfunction in a female hypertensive:a case report[J].Afr J Med Sci,2011,40(3):273~275.
[12]Ma R,Yu J,Xu D,et al.Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension[J].J Hypertens,2012,30(1):210~216.