CREBRF基因及其功能研究进展
|
摘要
繁殖性状作为多基因控制的数量性状,受到多种转录调控因子、信号通路的共同调控,直接影响规模化养殖生产的经济效益,提高繁殖力已成为当今家畜遗传育种的重要目标之一。Luman/CREB3募集因子(LRF或CREBRF)是一种未折叠蛋白应答响应亮氨酸拉链转录因子,其在进化过程中保持稳定且具有保守的蛋白结构。近年来的研究发现,CREBRF基因在机体代谢、疾病治疗以及动物繁殖调控过程中发挥着重要功能。本文主要就CREBRF基因的发现与结构特征、表达规律及其与动物繁殖相关的研究进展进行综述,为深入挖掘CREBRF基因在动物机体中的生物学功能奠定基础。
As a quantitative trait controlled by multiple genes, reproductive traits is regulated by many transcriptional regulatory factors and signaling pathways, which directly affect the economic benefits of scale breeding production. And improving breeding capacity has become one of the important goal of livestock genetic breeding currently. Luman/CREB3 recruiting factor(LRF or CREBRF), is an unfolded protein response response leucine zipper transcription factor, which remains stable and has a conservative protein structure during evolution. In recent years, it has been found to play an important role in body metabolism, disease treatment and animal reproductive regulation process. This paper mainly reviews the current status of studies on the discovery and structure characteristics, expression pattern, research progress related to animal reproduction of CREBRF gene, laying a foundation for further exploring the biological functions of CREBRF gene in animal organisms.
As a quantitative trait controlled by multiple genes, reproductive traits is regulated by many transcriptional regulatory factors and signaling pathways, which directly affect the economic benefits of scale breeding production. And improving breeding capacity has become one of the important goal of livestock genetic breeding currently. Luman/CREB3 recruiting factor(LRF or CREBRF), is an unfolded protein response response leucine zipper transcription factor, which remains stable and has a conservative protein structure during evolution. In recent years, it has been found to play an important role in body metabolism, disease treatment and animal reproductive regulation process. This paper mainly reviews the current status of studies on the discovery and structure characteristics, expression pattern, research progress related to animal reproduction of CREBRF gene, laying a foundation for further exploring the biological functions of CREBRF gene in animal organisms.
引文
[1]Audas T E, Li Y, Liang G, et al. A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of theunfolded protein response[J]. Mol Cell Biol, 2008, 28:3952-3966.
[2]杨延周. LRF在雌性小鼠生殖及卵巢颗粒细胞凋亡过程中的作用研究[D].杨凌:西北农林科技大学, 2012:46-90.
[3]Yang Y, Lin P, Chen F, et al. Luman recruiting factor regulatesendoplasmic reticulum stress in mouse ovarian granulosa cellapoptosis[J]. Theriogenology, 2013, 79(4):633-639.
[4]Martyn A C, Choleris E, Gillis D J, et al. Luman/CREB3recruitment factor regulates glucocorticoid receptor activityand is essential for prolactin-mediated maternal instinct[J].Mol Cell Biol, 2012, 32(24):5140-5150.
[5]Yang D, Jiang T, Liu J, et al. CREB3 regulatory factor-mTOR-autophagy regulates goat endometrial function during earlypregnancy[J]. Biol Reprod, 2018, 98(5):713-721.
[6]Audas T E, Hardy-Smith P W, Penney J, et al. Characteriza-tion of nuclear foci-targeting of Luman/CREB3 recruitmentfactor(LRF/CREBRF)and its potential role in inhibition ofherpes simplex virus-1 replication[J]. Eur J Cell Biol, 2016,95(12):611-622.
[7]Xue H, Zhang J, Guo X, et al. CREBRF is a potent tumorsuppressor of glioblastoma by blocking hypoxia-inducedautophagy via the CREB3/ATG5 pathway[J]. Int J Oncol,2016, 49(2):519-528.
[8]Minster R L, Hawley N L, Su C T, et al. A thrifty variant inCREBRF strongly influences body mass index in Samoans[J].Nat Genet, 2016, 48(9):1049-1054.
[9]Loos R J F. CR EBR F var iant increases obesit y r isk andprotects against diabetes in Samoans[J]. Nat Genet, 2016,48(9):976-978.
[10]Yang Y, Jin Y, Lin P, et al. The expression and localization ofLRF in the female reproductive tract of cycling mice throughoutthe estrous cycle[J]. J Immunoassay Immunochem, 2013, 34(4):313-322.
[11]Yang Y, Jin Y, Martyn A C, et al. Expression pattern imp-licates a potent ial role for lu ma n recr uit ment factor i nthe process of implantation in uter i and development ofpreimplantation embryos in mice[J]. J Reprod Develop, 2013,59(3):245-251.
[12]Raggo C, Rapin N, Stirling J, et al. Luman, the cellular cou-nter par t of her pes simplex vir us V P16, is processed byregulated intramembrane proteolysis[J]. Mol Cell Biol, 2002,22(16):5639-5649.
[13]Liang G, Audas T E, Li Y, et al. Luman/CREB3 induces tran-scription of the endoplasmic reticulum(ER)stress responseprotein Herp through an ER stress response element[J]. MolCell Biol, 2006, 26(21):7999-8010.
[14]Stirling J, O'Hare P. CREB4, a transmembrane bZip tran-scription factor and potential new substrate for regulation andcleavage by S1P[J]. Mol Biol Cell, 2006, 17(1):413-426.
[15]Blot G, Lopez-Verges S, Treand C, et al. Luman, a new partnerof HIV-1 TMgp41, interferes with tat-mediated transcription ofthe HIV-1 LTR[J]. J Mol Biol, 2006, 364(5):1034-1047.
[16]Jang S W, Kim Y S, Kim Y R, et al. Regulation of humanLZI P expression by N F-kappaB and its i nvolvement i nmonocyte cell migration induced by Lkn-1[J]. J Biol Chem,2007, 282(15):11092-11100.
[17]Sung H J, Kim Y S, Kang H, et al. Human LZIP induces mo-nocyteCC chemokine receptor 2 expression leading to enhancementof monocyte chemoattractant protein 1/CCL2-induced cellmigration[J]. Exp Mol Med, 2008, 40(3):332-338.
[18]Eleveld-Trancikova D, Sanecka A, van Hout-Kuijer M A, et al.DC-STAMP interacts with ER-resident transcription factorLUMAN which becomes activated during DC maturation[J].Mol Immunol, 2010, 47(11):1963-1973.
[19]Kang H, Kim Y S, Ko J. A novel isofor m of human LZIPnegatively regulates the transactivation of the glucocorticoidreceptor[J]. Mol Endocrinol, 2009, 23(11):1746-1757.
[20]Knez J, Piluso D, Bilan P, et al. Host cell factor-1 and E2F4interact via multiple determinants in each protein[J]. Mol CellBiochem, 2006, 288(1-2):79-90.
[21]Tyagi S, Chabes A L, Wysocka J, et al. E2F activation of Sphase promoters via association with HCF-1 and the MLLfamily of histone H3K4 methyltransferases[J]. Mol Cell, 2007,27(1):107-119.
[22]杨延周,李倩,兰向莉,等. LRF在围植入期小鼠子宫中的表达:参与调节胚胎植入及蜕膜化[C].兰州:中国畜牧兽医学会,2012.
[23]李晓.内质网应激调节蛋白LRF在小鼠子宫内膜蜕膜化中的作用[D].杨凌:西北农林科技大学, 2016:90-92.
[24]Sroga J M, Ma X, Das S K. Developmental regulation ofdecidual cell polyploidy at the site of implantation[J]. FrontBiosci, 2011, 4(4):1475-1486.
[25]Li X, Lin P, Chen F, et al. Luman recruiting factor is involvedin stromal cell proliferation during decidualization in mice[J].Cell Tissue Res, 2016, 365(2):437-447.
[26]Zhu H, Hou C C, Luo L F, et al. Endometrial stromal cellsand decidualized stromal cells:origins, transformation andfunctions[J]. Gene, 2014, 551(1):1-14.
[27]Brandeis M, Rosewell I, Carrington M, et al. Cyclin B2-nullmice develop normally and are fertile whereas cyclin B1-nullmice die in utero[J]. P Natl Acad Sci, 1998, 95(8):4344-4349.
[28]Kim H, Bhattacharya A, Qi L. Endoplasmic reticulum qualitycontrol in cancer:Friend or foe[J]. Semin Cancer Biol, 2015,33:25-33.
[29]Wang Q, Groenendyk J, Michalak M. Glycoprotein qualitycontro and endoplasmic reticulum stress[J]. Molecules, 2015,20(8):13689-13704.
[30]Wang M, Kaufman R J. Protein misfolding in the endoplasmicreticulum as a conduit to human disease[J]. Nature, 2016,529(7586):326-335.
[31]Woehlbier U, Hetz C. Modulating stress responses by theUPRosome:amatter of life and death[J]. Trends BiochemSci, 2011, 36(6):329-337.
[32]J?ger R, Bertrand M J, Gorman A M, et al. The unfolded prot-ein response at the crossroads of cellular life and death duringendoplasmic reticulum stress[J]. Biol Cell, 2012, 104(5):259-270.
[33]Credle J J, Forcelli P A, Delannoy M, et al.α-Synucleinme-diated inhibition of ATF6 processing into COPII vesiclesdisrupts UPR signaling in Parkinson's disease[J]. NeurobiolDis, 2015, 76:112-125.
[34]Liu L, Liu C, Lu Y, et al. ER stress related factor ATF6 andcaspase-12 trigger apoptosis in neonatal hypoxic-ischemicencephalopathy[J]. Int J Clin Exp Patho, 2015, 8(6):6960-6966.
[35]Madhusudhan T, Wang H, Dong W, et al. Defective podocyteinsulin signalling through p85-XBP1 promotes ATF6-dependentmaladaptive ER-stress response in diabetic nephropathy[J]. NatCommun, 2015, 6:6496.
[36]Lu H, Hao L, Li S, et al. Elevated circulating stearic acid leadsto a major lipotoxic effect on mouse pancreatic beta cellsin hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway[J]. Diabetologia, 2016, 59(6):1247-1257.
[37]Erickson G F, Magoffin D A, Cragun J R, et al. The effects ofinsulin and insulin-like growth factors-I and-II on estradiolproduction by granulose cells of polycystic ovaries[J]. J ClinEndocr Metab, 1990, 70(4):894-902.
[38]Drummond A E. The role of steroids in follicular growth[J].Reprod Biol Endocrin, 2006, 4(1):16.
[39]Gilchrist R B, Ritter L J, Armstrong D T. Oocyte-somatic cellinteractions during follicle development in mammals[J]. AnimReprod Sci, 2004, 82:431-446.
[40]Su Y Q, Sugiura K, Eppig J J. Mouse oocyte control of gra-nulosa cell development and function:paracrine regulation ofcumulus cell metabolism[J]. Semin Reprod Med, 2009, 27(1):32-42.
[41]Wu L Y, Dunning K R, Yang X, et al. High-fat diet causeslipotoxicity responses in cumulus–oocyte complexes anddecreased fertilization rates[J]. Endocrinology, 2010, 151(11):5438-5445.
[42]Robker R L, Wu L L, Yang X. Inflammatory pathways linkingobesity and ovarian dysfunction[J]. J Reprod Immunol, 2011,88(2):142-148.
[43]Lin P, Yang Y, Li X, et al. Endoplasmic reticulum stress isinvolved in granulosa cell apoptosis during follicular atresiain goat ovaries[J]. Mol Reprod Dev, 2012, 79(6):423-432.
[44]Fernández A, Ordó?ez R, Reiter R J, et al. Melatonin andendoplasmic reticulum stress:relation to autophagy andapoptosis[J]. J Pineal Res, 2015, 59(3):292-307.
[45]Johnson A L. Granulosa cell apoptosis:conservation of cellsignaling in an avian ovarian model system.[J]. Biol SignalRecept, 2000, 9(2):96-101.
[46]Audas T E, Li Y, Liang G, et al. 2. Luman/CREB3 and LRF,novel players in the mammalian unfolded protein response[J].Exp Gerontol, 2009, 44(1-2):126-127.
[2]杨延周. LRF在雌性小鼠生殖及卵巢颗粒细胞凋亡过程中的作用研究[D].杨凌:西北农林科技大学, 2012:46-90.
[3]Yang Y, Lin P, Chen F, et al. Luman recruiting factor regulatesendoplasmic reticulum stress in mouse ovarian granulosa cellapoptosis[J]. Theriogenology, 2013, 79(4):633-639.
[4]Martyn A C, Choleris E, Gillis D J, et al. Luman/CREB3recruitment factor regulates glucocorticoid receptor activityand is essential for prolactin-mediated maternal instinct[J].Mol Cell Biol, 2012, 32(24):5140-5150.
[5]Yang D, Jiang T, Liu J, et al. CREB3 regulatory factor-mTOR-autophagy regulates goat endometrial function during earlypregnancy[J]. Biol Reprod, 2018, 98(5):713-721.
[6]Audas T E, Hardy-Smith P W, Penney J, et al. Characteriza-tion of nuclear foci-targeting of Luman/CREB3 recruitmentfactor(LRF/CREBRF)and its potential role in inhibition ofherpes simplex virus-1 replication[J]. Eur J Cell Biol, 2016,95(12):611-622.
[7]Xue H, Zhang J, Guo X, et al. CREBRF is a potent tumorsuppressor of glioblastoma by blocking hypoxia-inducedautophagy via the CREB3/ATG5 pathway[J]. Int J Oncol,2016, 49(2):519-528.
[8]Minster R L, Hawley N L, Su C T, et al. A thrifty variant inCREBRF strongly influences body mass index in Samoans[J].Nat Genet, 2016, 48(9):1049-1054.
[9]Loos R J F. CR EBR F var iant increases obesit y r isk andprotects against diabetes in Samoans[J]. Nat Genet, 2016,48(9):976-978.
[10]Yang Y, Jin Y, Lin P, et al. The expression and localization ofLRF in the female reproductive tract of cycling mice throughoutthe estrous cycle[J]. J Immunoassay Immunochem, 2013, 34(4):313-322.
[11]Yang Y, Jin Y, Martyn A C, et al. Expression pattern imp-licates a potent ial role for lu ma n recr uit ment factor i nthe process of implantation in uter i and development ofpreimplantation embryos in mice[J]. J Reprod Develop, 2013,59(3):245-251.
[12]Raggo C, Rapin N, Stirling J, et al. Luman, the cellular cou-nter par t of her pes simplex vir us V P16, is processed byregulated intramembrane proteolysis[J]. Mol Cell Biol, 2002,22(16):5639-5649.
[13]Liang G, Audas T E, Li Y, et al. Luman/CREB3 induces tran-scription of the endoplasmic reticulum(ER)stress responseprotein Herp through an ER stress response element[J]. MolCell Biol, 2006, 26(21):7999-8010.
[14]Stirling J, O'Hare P. CREB4, a transmembrane bZip tran-scription factor and potential new substrate for regulation andcleavage by S1P[J]. Mol Biol Cell, 2006, 17(1):413-426.
[15]Blot G, Lopez-Verges S, Treand C, et al. Luman, a new partnerof HIV-1 TMgp41, interferes with tat-mediated transcription ofthe HIV-1 LTR[J]. J Mol Biol, 2006, 364(5):1034-1047.
[16]Jang S W, Kim Y S, Kim Y R, et al. Regulation of humanLZI P expression by N F-kappaB and its i nvolvement i nmonocyte cell migration induced by Lkn-1[J]. J Biol Chem,2007, 282(15):11092-11100.
[17]Sung H J, Kim Y S, Kang H, et al. Human LZIP induces mo-nocyteCC chemokine receptor 2 expression leading to enhancementof monocyte chemoattractant protein 1/CCL2-induced cellmigration[J]. Exp Mol Med, 2008, 40(3):332-338.
[18]Eleveld-Trancikova D, Sanecka A, van Hout-Kuijer M A, et al.DC-STAMP interacts with ER-resident transcription factorLUMAN which becomes activated during DC maturation[J].Mol Immunol, 2010, 47(11):1963-1973.
[19]Kang H, Kim Y S, Ko J. A novel isofor m of human LZIPnegatively regulates the transactivation of the glucocorticoidreceptor[J]. Mol Endocrinol, 2009, 23(11):1746-1757.
[20]Knez J, Piluso D, Bilan P, et al. Host cell factor-1 and E2F4interact via multiple determinants in each protein[J]. Mol CellBiochem, 2006, 288(1-2):79-90.
[21]Tyagi S, Chabes A L, Wysocka J, et al. E2F activation of Sphase promoters via association with HCF-1 and the MLLfamily of histone H3K4 methyltransferases[J]. Mol Cell, 2007,27(1):107-119.
[22]杨延周,李倩,兰向莉,等. LRF在围植入期小鼠子宫中的表达:参与调节胚胎植入及蜕膜化[C].兰州:中国畜牧兽医学会,2012.
[23]李晓.内质网应激调节蛋白LRF在小鼠子宫内膜蜕膜化中的作用[D].杨凌:西北农林科技大学, 2016:90-92.
[24]Sroga J M, Ma X, Das S K. Developmental regulation ofdecidual cell polyploidy at the site of implantation[J]. FrontBiosci, 2011, 4(4):1475-1486.
[25]Li X, Lin P, Chen F, et al. Luman recruiting factor is involvedin stromal cell proliferation during decidualization in mice[J].Cell Tissue Res, 2016, 365(2):437-447.
[26]Zhu H, Hou C C, Luo L F, et al. Endometrial stromal cellsand decidualized stromal cells:origins, transformation andfunctions[J]. Gene, 2014, 551(1):1-14.
[27]Brandeis M, Rosewell I, Carrington M, et al. Cyclin B2-nullmice develop normally and are fertile whereas cyclin B1-nullmice die in utero[J]. P Natl Acad Sci, 1998, 95(8):4344-4349.
[28]Kim H, Bhattacharya A, Qi L. Endoplasmic reticulum qualitycontrol in cancer:Friend or foe[J]. Semin Cancer Biol, 2015,33:25-33.
[29]Wang Q, Groenendyk J, Michalak M. Glycoprotein qualitycontro and endoplasmic reticulum stress[J]. Molecules, 2015,20(8):13689-13704.
[30]Wang M, Kaufman R J. Protein misfolding in the endoplasmicreticulum as a conduit to human disease[J]. Nature, 2016,529(7586):326-335.
[31]Woehlbier U, Hetz C. Modulating stress responses by theUPRosome:amatter of life and death[J]. Trends BiochemSci, 2011, 36(6):329-337.
[32]J?ger R, Bertrand M J, Gorman A M, et al. The unfolded prot-ein response at the crossroads of cellular life and death duringendoplasmic reticulum stress[J]. Biol Cell, 2012, 104(5):259-270.
[33]Credle J J, Forcelli P A, Delannoy M, et al.α-Synucleinme-diated inhibition of ATF6 processing into COPII vesiclesdisrupts UPR signaling in Parkinson's disease[J]. NeurobiolDis, 2015, 76:112-125.
[34]Liu L, Liu C, Lu Y, et al. ER stress related factor ATF6 andcaspase-12 trigger apoptosis in neonatal hypoxic-ischemicencephalopathy[J]. Int J Clin Exp Patho, 2015, 8(6):6960-6966.
[35]Madhusudhan T, Wang H, Dong W, et al. Defective podocyteinsulin signalling through p85-XBP1 promotes ATF6-dependentmaladaptive ER-stress response in diabetic nephropathy[J]. NatCommun, 2015, 6:6496.
[36]Lu H, Hao L, Li S, et al. Elevated circulating stearic acid leadsto a major lipotoxic effect on mouse pancreatic beta cellsin hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway[J]. Diabetologia, 2016, 59(6):1247-1257.
[37]Erickson G F, Magoffin D A, Cragun J R, et al. The effects ofinsulin and insulin-like growth factors-I and-II on estradiolproduction by granulose cells of polycystic ovaries[J]. J ClinEndocr Metab, 1990, 70(4):894-902.
[38]Drummond A E. The role of steroids in follicular growth[J].Reprod Biol Endocrin, 2006, 4(1):16.
[39]Gilchrist R B, Ritter L J, Armstrong D T. Oocyte-somatic cellinteractions during follicle development in mammals[J]. AnimReprod Sci, 2004, 82:431-446.
[40]Su Y Q, Sugiura K, Eppig J J. Mouse oocyte control of gra-nulosa cell development and function:paracrine regulation ofcumulus cell metabolism[J]. Semin Reprod Med, 2009, 27(1):32-42.
[41]Wu L Y, Dunning K R, Yang X, et al. High-fat diet causeslipotoxicity responses in cumulus–oocyte complexes anddecreased fertilization rates[J]. Endocrinology, 2010, 151(11):5438-5445.
[42]Robker R L, Wu L L, Yang X. Inflammatory pathways linkingobesity and ovarian dysfunction[J]. J Reprod Immunol, 2011,88(2):142-148.
[43]Lin P, Yang Y, Li X, et al. Endoplasmic reticulum stress isinvolved in granulosa cell apoptosis during follicular atresiain goat ovaries[J]. Mol Reprod Dev, 2012, 79(6):423-432.
[44]Fernández A, Ordó?ez R, Reiter R J, et al. Melatonin andendoplasmic reticulum stress:relation to autophagy andapoptosis[J]. J Pineal Res, 2015, 59(3):292-307.
[45]Johnson A L. Granulosa cell apoptosis:conservation of cellsignaling in an avian ovarian model system.[J]. Biol SignalRecept, 2000, 9(2):96-101.
[46]Audas T E, Li Y, Liang G, et al. 2. Luman/CREB3 and LRF,novel players in the mammalian unfolded protein response[J].Exp Gerontol, 2009, 44(1-2):126-127.