环境PM_(2.5)对慢性阻塞性肺疾病的致病机制研究
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摘要
环境PM_(2.5)对人群健康的影响引起全球密切关注。慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)严重威胁人类的健康。文章就近年来环境PM_(2.5)与COPD的相关流行病学研究、环境PM_(2.5)引起COPD的致病机制研究作一综述,以期为COPD的临床治疗以及人群预防提供科学参考。
The impact of ambient PM_(2.5) on human health has become a global concern. Chronic obstructive pulmonary disease(COPD) is one of the most threatening diseases to human health. The paper presents a review on the related studies on the epidemiology of COPD and the pathogenic mechanism of COPD induced by exposure to PM_(2.5)in an attempt to obtain scientific knowledge to inform practitioners of clinical treatment and prevention of COPD.
The impact of ambient PM_(2.5) on human health has become a global concern. Chronic obstructive pulmonary disease(COPD) is one of the most threatening diseases to human health. The paper presents a review on the related studies on the epidemiology of COPD and the pathogenic mechanism of COPD induced by exposure to PM_(2.5)in an attempt to obtain scientific knowledge to inform practitioners of clinical treatment and prevention of COPD.
引文
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[27] CHEN Y C ,CHIANG H C ,HSU C Y ,et al.Ambient PM2.5-bound polycyclic aromatic hydrocarbons (PAHs) in Changhua County,central Taiwan:Seasonal variation,source apportionment and cancer risk assessment [J].Environ Pollut,2016,218(16):372-382.
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[31] JIN Y,WAN Y,CHEN G,et al.Treg/IL-17 ratio and Treg differentiation in patients with COPD [J].PLoS One,2014,9(10):e111044.
[32] BI YF,GUO F Y,YANG L,et al.Phyllostachys edulis forest reduces atmospheric PM2.5 and PAHs on hazy days at suburban area [J].Sci Rep,2018,8(1):12591.
[33] MIYARA M,YOSHIOKA Y,KITOH A,et al.Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor [J].Immunity,2009,30(6):899-911.
[34] HOU J,SUN Y,HAO Y,et al.Imbalance between subpopulations of regulatory T cells in COPD [J].Thorax,2013,68(12):1131-9.
[35] GU X Y,CHU X,ZENG X L,et al.Effects of PM2.5 exposure on the Notch signaling pathway and immune imbalance in chronic obstructive pulmonary disease [J].Environ Pollut,2017,226:163-173.
[36] AMSEN D,HELBIG C,BACKER R A.Notch in T Cell Differentiation:all Things Considered [J].Trends Immunol,2015,36(12):802-814.
[37] YANG L,MA Q,LI L,et al.Effects of airborne fine particulate matters on pulmonary inflammation injury and Th17/Treg balance of sub-chronic exposure mice [J].Wei Sheng Yan Jiu,2014,43(3):387-392.
[2] XUE X,CHEN J,SUN B,et al.Temporal trends in respiratory mortality and short-term effects of air pollutants in Shenyang,China [J].Environ Sci Pollut Res Int,2018,25(12):11468-11479.
[3] TIAN Y,LIU H,LIANG T,et al.Ambient air pollution and daily hospital admissions:a nationwide study in 218 Chinese cities [J].Environ Pollut,2018,242:1042-1049.
[4] COHEN A J,BRAUER M,BURNETT R,et al.Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution:an analysis of data from the Global Burden of Diseases Study 2015 [J].Lancet,2017,389(10082):1907-1918.
[5] ADELOYE D,CHUA S,LEE C,et al.Global and regional estimates of COPD prevalence:systematic review and meta-analysis [J].J Glob Health,2015,5(2):020415.
[6] GARVEY C.Recent updates in chronic obstructive pulmonary disease [J].Postgrad Med,2015,128(2):231-238.
[7] SCHIKOWSKI T,MILLS I C,ANDERSON H R,et al.Ambient air pollution:a cause of COPD [J].Eur Respir J,2014,43(1):250-263.
[8] SUN X W,CHEN P L,REN L,et al.The cumulative effect of air pollutants on the acute exacerbation of COPD in Shanghai,China [J].Sci Total Environ,2017,622-623:875-881.
[9] WU S,NI Y,LI H,et al.Short-term exposure to high ambient air pollution increases airway inflammation and respiratory symptoms in chronic obstructive pulmonary disease patients in Beijing,China [J].Environ Int,2016,94:76-82.
[10] GUO C,ZHANG Z,LAU A K H,et al.Effect of long-term exposure to fine particulate matter on lung function decline and risk of chronic obstructive pulmonary disease in Taiwan:a longitudinal,cohort study [J].Lancet Planet Health,2018,2(3):e114-e125.
[11] CHOWDHURY S,DEY S.Cause-specific premature death from ambient PM2.5,exposure in India:estimate adjusted for baseline mortality [J].Environ Int,2016,91:283-290.
[12] PINAULT L,TJEPKEMA M,CROUSE D L,et al.Risk estimates of mortality attributed to low concentrations of ambient fine particulate matter in the Canadian community health survey cohort [J].Environ Health,2016,15(1):1-15.
[13] LECLERCQ B,PLATEL A,ANTHERIEU S,et al.Genetic and epigenetic alterations in normal and sensitive COPD-diseased human bronchial epithelial cells repeatedly exposed to air pollution-derived PM2.5 [J].Environ Pollut,2017,230:163-177.
[14] LI R,KOU X,XIE L,et al.Effects of ambient PM2.5 on pathological injury,inflammation,oxidative stress,metabolic enzyme activity,and expression of c-fos and c-jun in lungs of rats [J].Environ Sci Pollut Res Int,2015,22(24):1-10.
[15] LI T,HU R,CHEN Z,et al.Fine particulate matter (PM2.5):the culprit for chronic lung diseases in China [J].Chronic Dis Transl Med,2018,4(3):176-186.
[16] BARNES P J.Inflammatory mechanisms in patients with chronic obstructive pulmonary disease [J].J Allergy Clin Immunol,2016,138(1):16-27.
[17] CABRERA-FUENTES H A,LOPEZ M L,MCCURDY S,et al.Regulation of monocyte/macrophage polarisation by extracellular RNA [J].Thromb Haemost,2015,114(3):473-481.
[18] ZHAO Q,HUI C,TAO Y,et al.Direct effects of airborne PM2.5 exposure on macrophage polarizations [J].Biochim Biophys Acta,2016,1860(12):2835-2843.
[19] HE M,ICHINOSE T,YOSHIDA S,et al.PM2.5-induced lung inflammation in mice:differences of inflammatory response in macrophages and type II alveolar cells [J].J Appl Toxicol,2017,37(10):1203-1218.
[20] GAO W,LI L,WANG Y,et al.Bronchial epithelial cells:the key effector cells in the pathogenesis of chronic obstructive pulmonary disease?[J].Respirology,2015,20(5):722-729.
[21] ZHANG K,GUO L,WEI Q,et al.COPD rat model is more susceptible to cold stress and PM2.5 exposure and the underlying mechanism [J].Environ Pollut,2018,241:26-34.
[22] FARAHI N,PAIGE E,BALLA J,et al.Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma [J].Hum Mol Genet,2017,26(8):1584-1596.
[23] KOUASSI K S,BILLET S,GAR?ON G,et al.Oxidative damage induced in A549 cells by physically and chemically characterized air particulate matter (PM2.5) collected in Abidjan,Cote d'Ivoire [J].J Appl Toxicol,2010,30(4):310-320.
[24] WANG J ,HUANG J ,WANG L ,et al.Urban particulate matter triggers lung inflammation via the ROS-MAPK-NF-κB signaling pathway [J].J Thorac Dis,2017,9(11):4398-4412.
[25] LIU C W,LEE T L,CHEN Y C,et al.PM2.5-induced oxidative stress increases intercellular adhesion molecule-1 expression in lung epithelial cells through the IL-6/AKT/STAT3/NF-κB-dependent pathway [J].Part Fibre Toxicol,2018,15(1):4.
[26] LAWAL A O.Air particulate matter induced oxidative stress and inflammation in cardiovascular disease and atherosclerosis:the role of Nrf2 and AhR-mediated pathways [J].Toxicol Lett,2017,270:88-95.
[27] CHEN Y C ,CHIANG H C ,HSU C Y ,et al.Ambient PM2.5-bound polycyclic aromatic hydrocarbons (PAHs) in Changhua County,central Taiwan:Seasonal variation,source apportionment and cancer risk assessment [J].Environ Pollut,2016,218(16):372-382.
[28] CHEN Y ,LI X ,ZHU T ,et al.PM2.5 -bound PAHs in three indoor and one outdoor air in Beijing:concentration,source and health risk assessment [J].Sci Total Environ,2017,586:255-264.
[29] YANG L,WANG W C,LUNG S C,et al.Polycyclic aromatic hydrocarbons are associated with increased risk of chronic obstructive pulmonary disease during haze events in China [J].Sci Total Environ,2017,574:1649-1658.
[30] BRUSSELLE G G,JOOS G F,BRACKE K R.New insights into the immunology of chronic obstructive pulmonary disease [J].Lancet,2011,378(9795):1015-1026.
[31] JIN Y,WAN Y,CHEN G,et al.Treg/IL-17 ratio and Treg differentiation in patients with COPD [J].PLoS One,2014,9(10):e111044.
[32] BI YF,GUO F Y,YANG L,et al.Phyllostachys edulis forest reduces atmospheric PM2.5 and PAHs on hazy days at suburban area [J].Sci Rep,2018,8(1):12591.
[33] MIYARA M,YOSHIOKA Y,KITOH A,et al.Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor [J].Immunity,2009,30(6):899-911.
[34] HOU J,SUN Y,HAO Y,et al.Imbalance between subpopulations of regulatory T cells in COPD [J].Thorax,2013,68(12):1131-9.
[35] GU X Y,CHU X,ZENG X L,et al.Effects of PM2.5 exposure on the Notch signaling pathway and immune imbalance in chronic obstructive pulmonary disease [J].Environ Pollut,2017,226:163-173.
[36] AMSEN D,HELBIG C,BACKER R A.Notch in T Cell Differentiation:all Things Considered [J].Trends Immunol,2015,36(12):802-814.
[37] YANG L,MA Q,LI L,et al.Effects of airborne fine particulate matters on pulmonary inflammation injury and Th17/Treg balance of sub-chronic exposure mice [J].Wei Sheng Yan Jiu,2014,43(3):387-392.