重金属影响中枢神经系统的微生物-肠-脑轴途径
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摘要
人类生产活动排放出的过量重金属直接危害人体健康.目前,有关重金属诱导中枢神经系统疾病发生的研究受到越来越多的关注,经胃肠道吸收是重金属进入人体的主要途径之一,而肠道作为人体内最大的微生态系统,对维持神经系统的正常功能具有重要的生物作用.本文对表征肠道微生物多样性改变的测序方法,以及环境中广泛存在的重金属锰(Mn)、铅(Pb)、镉(Cd)、砷(As)通过影响微生物-肠-脑轴造成神经系统疾病的潜在机制进行总结,并对重金属等污染物基于肠道微生物引发神经系统疾病的预防和治疗进行展望.
Human production activities release excessive heavy metals and directly harm human health. At present, the researches on the heavy metal-induced central nervous system diseases has received increasing attention. Absorption through the gastrointestinal tract is one of the major pathways for the entry of heavy metals into the human body. The intestine is the largest micro-ecological system in the human body, which plays an important biological role in maintaining the normal functions of the nervous system. This study describes the sequencing method for characterizing the diversity of intestinal microbes, and summarizes the potential mechanisms of the microbe-gut-brain axis effects on the neurological diseases caused by the widespread presence of heavy metals, including manganese(Mn), lead(Pb), cadmium(Cd), and arsenic(As) in the environment. We will provide the prevention and treatment of heavy metals-induced neurological diseases based on intestinal microbes.
Human production activities release excessive heavy metals and directly harm human health. At present, the researches on the heavy metal-induced central nervous system diseases has received increasing attention. Absorption through the gastrointestinal tract is one of the major pathways for the entry of heavy metals into the human body. The intestine is the largest micro-ecological system in the human body, which plays an important biological role in maintaining the normal functions of the nervous system. This study describes the sequencing method for characterizing the diversity of intestinal microbes, and summarizes the potential mechanisms of the microbe-gut-brain axis effects on the neurological diseases caused by the widespread presence of heavy metals, including manganese(Mn), lead(Pb), cadmium(Cd), and arsenic(As) in the environment. We will provide the prevention and treatment of heavy metals-induced neurological diseases based on intestinal microbes.
引文
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[19] DAVIDSON R M, EPPERSON L E. Microbiome sequencing methods for studying human diseases[J]. Methods Mol Biol, 2018, 1706: 77-90.
[20] CHI L, BIAN X, GAO B, et al. The effects of an environmentally relevant level of arsenic on the gut microbiome and its functional metagenome[J]. Toxicological Sciences An Official Journal of the Society of Toxicology, 2017, 160(2):193-204.
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[22] MILATOVIC D, RC ZMS. Oxidative damage and neurodegeneration in manganese-induced neurotoxicity[J]. Toxicology & Applied Pharmacology, 2009, 240(2): 219-225.
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[30] IANNIELLO R G, RICCIARDI A, PARENTE E, et al. Aeration and supplementation with heme and menaquinone affect survival to stresses and antioxidant capability of lactobacillus casei strains[J]. LWT-Food Science and Technology, 2015, 60(2): 817-824.
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