长链非编码RNA生物学特性和功能研究进展
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摘要
长链非编码RNA(long non-coding RNA,lncRNA)是近年来备受关注的长度大于200 nt的内源性非蛋白编码RNA。大量资料显示其参与了哺乳动物许多重要生理、病理过程,并在其中起到非常重要的生物学作用。主要针对lncRNA的基本概念、生物学特性及主要生物学功能进行综述,为lncRNA的相关研究提供参考。
lncRNA was an endogenous non-protein encoded RNA with length larger than 200 nt which had attracted much attention in recent years. A lot of reports revealed that lncRNA was involved in many important physiological and pathological processes in animals and played a very important biological role. The basic concept,biological characteristics and main biological function were briefly introduced to provide reference for lncRNA related research.
lncRNA was an endogenous non-protein encoded RNA with length larger than 200 nt which had attracted much attention in recent years. A lot of reports revealed that lncRNA was involved in many important physiological and pathological processes in animals and played a very important biological role. The basic concept,biological characteristics and main biological function were briefly introduced to provide reference for lncRNA related research.
引文
[1]Wang K C,Chang H Y.Molecular mechanisms of long noncoding RNAs[J].Molecular Cell,2011,43(6):904-914.
[2]Vennin C,Adriaenssens E.Long non-coding RNA and messenger RNA-the meeting of two worlds[J].Journal of Thoracic Disease,2018,10(2):544.
[3]Kapranov P,Cheng J,Dike S,et al.RNA maps reveal new RNA classes and a possible function for pervasive transcription[J].Science,2007,316(5830):1484-1488.
[4]Kiyosawa H,Mise N,Iwase S,et al.Disclosing hidden transcripts:Mouse natural sense antisense transcripts tend to be poly(A)negative and nuclear localized[J].Genome Research,2005,15(4):463-474.
[5]Renoux A J,Todd P K.Neurodegeneration the RNA way[J].Progress in Neurobiology,2012,97(2):173-189.
[6]Mazar J,Zhao W,Khalil A M,et al.The functional characterization of long noncoding RNA SPRY4-IT1 in human melanoma Cells[J].Oncotarget,2014(19):8959.
[7]Cabili M N,Trapnell C,Goff L,et al.Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses[J].Genes&Development,2011,25(18):1915-1927.
[8]Hon C C,Ramilowski J A,Harshbarger J,et al.An atlas of human long non-coding RNAs with accurate 5′ends[J].Nature,2017,543(7644):199.
[9]Guttman M,Amit I,Garber M,et al.Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in Mammals[J].Nature,2009,458(7235):223.
[10]Ravasi T,Suzuki H,Pang K C,et al.Experimental validation of the regulated expression of large numbers of noncoding RNAs from the mouse genome[J].Genome Research,2006,16(1):11-19.
[11]Yunusov D,Anderson L,DaSilva L F,et al.HIPSTR and thousands of lncRNAs are heterogeneously expressed in human embryos,primordial germ cells and stable cell lines[J].Scientific Reports,2016(6):32753.
[12]Derrien T,Johnson R,Bussotti G,et al.The GENCODE v7catalog of human long noncoding RNAs:analysis of their gene structure,evolution,and expression[J].Genome Research,2012,22(9):1775-1789.
[13]Necsulea A,Soumillon M,Warnefors M,et al.The evolution of lncRNA repertoires and expression patterns in tetrapods[J].Nature,2014,505(7485):635.
[14]Palazzo A F,Lee E S.Non-coding RNA:what is functional and what is junk?[J].Frontiers in Genetics,2015(6):2.
[15]Kapusta A,Feschotte C.Volatile evolution of long noncoding RNA repertoires:mechanisms and biological implications[J].Trends in Genetics,2014,30(10):439-452.
[16]Prensner J R,Iyer M K,Balbin O A,et al.Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1,an unannotated lincRNA implicated in disease progression[J].Nature Biotechnology,2011,29(8):742.
[17]Cheng J,Kapranov P,Drenkow J,et al.Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution[J].Science,2005,308(5725):1149-1154.
[18]Ma L,Bajic V B,Zhang Z.On the classification of long non-coding RNAs[J].RNA biology,2013,10(6):924-933.
[19]Derrien T,Johnson R,Bussotti G,et al.The GENCODE v7catalog of human long noncoding RNAs:analysis of their gene structure,evolution,and expression[J].Genome Research,2012,22(9):1775-1789.
[20]Zhu J J,Fu H J,Wu Y G,et al.Function of lncRNAs and approaches to lncRNA-protein interactions[J].Science China Life Sciences,2013,56(10):876-885.
[21]Di Ruscio A,Ebralidze A K,Benoukraf T,et al.DNMT1-interacting RNAs block gene-specific DNA methylation[J].Nature,2013,503(7476):371.
[22]Castelo-Branco G,Amaral P P,Engstrm P G,et al.The noncoding snRNA 7SK controls transcriptional termination,poising,and bidirectionality in embryonic stem cells[J].Genome Biology,2013,14(9):R98.
[23]Cesana M,Cacchiarelli D,Legnini I,et al.A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA[J].Cell,2011,147(2):358-369.
[24]Fasanaro P,Greco S,Lorenzi M,et al.An integrated approach for experimental target identification of hypoxiainduced miR-210[J].Journal of Biological Chemistry,2009,284(50):35134-35143.
[25]黄素娟,陶聪,甄二东,等.冷刺激小鼠脂肪组织差异表达长链非编码RNA的初步研究[J].中国畜牧兽医,2015,42(11):2867-2872.
[26]Liu Q,Sun S,Yu W,et al.Altered expression of long noncoding RNAs during genotoxic stress-induced cell death in human glioma cells[J].Journal of Neuro-oncology,2015,122(2):283-292.
[27]SoléC,Nadal-Ribelles M,de Nadal E,et al.A novel role for lncRNAs in cell cycle control during stress adaptation[J].Current Genetics,2015,61(3):299-308.
[28]柳婧,潘求真,赵文博,等.通过CRISPR/Cas9技术打靶兔Myostatin基因[J].黑龙江八一农垦大学学报,2015(6):24-27.
[29]Mariner P D,Walters R D,Espinoza C A,et al.Human Alu RNA is a modular transacting repressor of mRNA transcription during heat shock[J].Molecular Cell,2008,29(4):499-509.
[30]Salim S.Oxidative stress and the central nervous system[J].Journal of Pharmacology and Experimental Therapeutics,2017,360(1):201-205.
[31]Mercer T R,Dinger M E,Mattick J S.Long non-coding RNAs:insights into functions[J].Nature Reviews Genetics,2009,10(3):155.
[32]Ng S Y,Lin L,Soh B S,et al.Long noncoding RNAs in development and disease of the central nervous system[J].Trends in Genetics,2013,29(8):461-468.
[33]Chen R,Li W X,Sun Y,et al.Comprehensive analysis of lncRNA and m RNA expression profiles in lung cancer[J].Clin Lab,2017,63:313-320.
[34]Liang W C,Ren J L,Wong C W,et al.LncRNA-NEFantagonized epithelial to mesenchymal transition and cancer metastasis via cis-regulating FOXA2 and inactivating Wnt-catenin signaling[J].Oncogene,2018(1):1445-1456.
[35]Lu D,Luo P,Wang Q,et al.lncRNA PVT1 in cancer:A review and meta-analysis[J].Clinica Chimica Acta,2017,474:1-7.
[36]王嵩,林红丽,王宇鹏,等.BRSV和BPIV-3双重PCR检测方法的建立及初步应用[J].黑龙江八一农垦大学学报,2014,26(5):35-38.
[37]Knoll M,Lodish H F,Sun L.Long non-coding RNAs as regulators of the endocrine system[J].Nature Reviews Endocrinology,2015,11(3):151.
[38]Hu G,Tang Q,Sharma S,et al.Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation[J].Nature Immunology,2013,14(11):1190.
[39]Kino T,Hurt D E,Ichijo T,et al.Noncoding RNA gas5 is a growth arrest-and starvation-associated repressor of the glucocorticoid receptor[J].Sci Signal,2010,33(107):692-702.
[40]Grote P,Wittler L,Hendrix D,et al.The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse[J].Developmental Cell,2013,24(2):206-214.
[41]Zhong J,Chuang S C,Bianchi R,et al.BC1 regulation of metabotropic glutamate receptor-mediated neuronal excitability[J].Journal of Neuroscience,2009,29(32):9977-9986.
[42]Liu J Y,Yao J,Li X M,et al.Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus[J].Cell Death&Disease,2014(10):1506.
[2]Vennin C,Adriaenssens E.Long non-coding RNA and messenger RNA-the meeting of two worlds[J].Journal of Thoracic Disease,2018,10(2):544.
[3]Kapranov P,Cheng J,Dike S,et al.RNA maps reveal new RNA classes and a possible function for pervasive transcription[J].Science,2007,316(5830):1484-1488.
[4]Kiyosawa H,Mise N,Iwase S,et al.Disclosing hidden transcripts:Mouse natural sense antisense transcripts tend to be poly(A)negative and nuclear localized[J].Genome Research,2005,15(4):463-474.
[5]Renoux A J,Todd P K.Neurodegeneration the RNA way[J].Progress in Neurobiology,2012,97(2):173-189.
[6]Mazar J,Zhao W,Khalil A M,et al.The functional characterization of long noncoding RNA SPRY4-IT1 in human melanoma Cells[J].Oncotarget,2014(19):8959.
[7]Cabili M N,Trapnell C,Goff L,et al.Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses[J].Genes&Development,2011,25(18):1915-1927.
[8]Hon C C,Ramilowski J A,Harshbarger J,et al.An atlas of human long non-coding RNAs with accurate 5′ends[J].Nature,2017,543(7644):199.
[9]Guttman M,Amit I,Garber M,et al.Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in Mammals[J].Nature,2009,458(7235):223.
[10]Ravasi T,Suzuki H,Pang K C,et al.Experimental validation of the regulated expression of large numbers of noncoding RNAs from the mouse genome[J].Genome Research,2006,16(1):11-19.
[11]Yunusov D,Anderson L,DaSilva L F,et al.HIPSTR and thousands of lncRNAs are heterogeneously expressed in human embryos,primordial germ cells and stable cell lines[J].Scientific Reports,2016(6):32753.
[12]Derrien T,Johnson R,Bussotti G,et al.The GENCODE v7catalog of human long noncoding RNAs:analysis of their gene structure,evolution,and expression[J].Genome Research,2012,22(9):1775-1789.
[13]Necsulea A,Soumillon M,Warnefors M,et al.The evolution of lncRNA repertoires and expression patterns in tetrapods[J].Nature,2014,505(7485):635.
[14]Palazzo A F,Lee E S.Non-coding RNA:what is functional and what is junk?[J].Frontiers in Genetics,2015(6):2.
[15]Kapusta A,Feschotte C.Volatile evolution of long noncoding RNA repertoires:mechanisms and biological implications[J].Trends in Genetics,2014,30(10):439-452.
[16]Prensner J R,Iyer M K,Balbin O A,et al.Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1,an unannotated lincRNA implicated in disease progression[J].Nature Biotechnology,2011,29(8):742.
[17]Cheng J,Kapranov P,Drenkow J,et al.Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution[J].Science,2005,308(5725):1149-1154.
[18]Ma L,Bajic V B,Zhang Z.On the classification of long non-coding RNAs[J].RNA biology,2013,10(6):924-933.
[19]Derrien T,Johnson R,Bussotti G,et al.The GENCODE v7catalog of human long noncoding RNAs:analysis of their gene structure,evolution,and expression[J].Genome Research,2012,22(9):1775-1789.
[20]Zhu J J,Fu H J,Wu Y G,et al.Function of lncRNAs and approaches to lncRNA-protein interactions[J].Science China Life Sciences,2013,56(10):876-885.
[21]Di Ruscio A,Ebralidze A K,Benoukraf T,et al.DNMT1-interacting RNAs block gene-specific DNA methylation[J].Nature,2013,503(7476):371.
[22]Castelo-Branco G,Amaral P P,Engstrm P G,et al.The noncoding snRNA 7SK controls transcriptional termination,poising,and bidirectionality in embryonic stem cells[J].Genome Biology,2013,14(9):R98.
[23]Cesana M,Cacchiarelli D,Legnini I,et al.A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA[J].Cell,2011,147(2):358-369.
[24]Fasanaro P,Greco S,Lorenzi M,et al.An integrated approach for experimental target identification of hypoxiainduced miR-210[J].Journal of Biological Chemistry,2009,284(50):35134-35143.
[25]黄素娟,陶聪,甄二东,等.冷刺激小鼠脂肪组织差异表达长链非编码RNA的初步研究[J].中国畜牧兽医,2015,42(11):2867-2872.
[26]Liu Q,Sun S,Yu W,et al.Altered expression of long noncoding RNAs during genotoxic stress-induced cell death in human glioma cells[J].Journal of Neuro-oncology,2015,122(2):283-292.
[27]SoléC,Nadal-Ribelles M,de Nadal E,et al.A novel role for lncRNAs in cell cycle control during stress adaptation[J].Current Genetics,2015,61(3):299-308.
[28]柳婧,潘求真,赵文博,等.通过CRISPR/Cas9技术打靶兔Myostatin基因[J].黑龙江八一农垦大学学报,2015(6):24-27.
[29]Mariner P D,Walters R D,Espinoza C A,et al.Human Alu RNA is a modular transacting repressor of mRNA transcription during heat shock[J].Molecular Cell,2008,29(4):499-509.
[30]Salim S.Oxidative stress and the central nervous system[J].Journal of Pharmacology and Experimental Therapeutics,2017,360(1):201-205.
[31]Mercer T R,Dinger M E,Mattick J S.Long non-coding RNAs:insights into functions[J].Nature Reviews Genetics,2009,10(3):155.
[32]Ng S Y,Lin L,Soh B S,et al.Long noncoding RNAs in development and disease of the central nervous system[J].Trends in Genetics,2013,29(8):461-468.
[33]Chen R,Li W X,Sun Y,et al.Comprehensive analysis of lncRNA and m RNA expression profiles in lung cancer[J].Clin Lab,2017,63:313-320.
[34]Liang W C,Ren J L,Wong C W,et al.LncRNA-NEFantagonized epithelial to mesenchymal transition and cancer metastasis via cis-regulating FOXA2 and inactivating Wnt-catenin signaling[J].Oncogene,2018(1):1445-1456.
[35]Lu D,Luo P,Wang Q,et al.lncRNA PVT1 in cancer:A review and meta-analysis[J].Clinica Chimica Acta,2017,474:1-7.
[36]王嵩,林红丽,王宇鹏,等.BRSV和BPIV-3双重PCR检测方法的建立及初步应用[J].黑龙江八一农垦大学学报,2014,26(5):35-38.
[37]Knoll M,Lodish H F,Sun L.Long non-coding RNAs as regulators of the endocrine system[J].Nature Reviews Endocrinology,2015,11(3):151.
[38]Hu G,Tang Q,Sharma S,et al.Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation[J].Nature Immunology,2013,14(11):1190.
[39]Kino T,Hurt D E,Ichijo T,et al.Noncoding RNA gas5 is a growth arrest-and starvation-associated repressor of the glucocorticoid receptor[J].Sci Signal,2010,33(107):692-702.
[40]Grote P,Wittler L,Hendrix D,et al.The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse[J].Developmental Cell,2013,24(2):206-214.
[41]Zhong J,Chuang S C,Bianchi R,et al.BC1 regulation of metabotropic glutamate receptor-mediated neuronal excitability[J].Journal of Neuroscience,2009,29(32):9977-9986.
[42]Liu J Y,Yao J,Li X M,et al.Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus[J].Cell Death&Disease,2014(10):1506.