乳腺癌超声征象与ER、C-erB-2表达的相关性研究
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摘要
目的:初步探讨乳腺癌超声特征与免疫组织化学因子ER、C-erbB-2表达的相关性,为临床乳腺癌术前辅助治疗及预后判断提供更多的信息和科学依据。方法: 103例乳腺癌均经病理组织学证实,且所有病例在治疗前均行乳腺超声检查,术后测定ER、C-erbB-2的表达。分析乳腺癌的超声征象与ER、C-erbB-2表达的相关性。结果:1.乳腺癌免疫组织化学因子ER、C-erbB-2的表达与肿块直径有相关性。2.有毛刺征的肿块比边缘光整的肿块有更高的ER、C-erbB-2阳性表达。3.腋窝淋巴结转移组中C-erbB-2阳性表达率高,ER阳性表达率低。4.彩色多普勒显示血流越丰富,C-erbB-2阳性表达率越高。结论:乳腺癌的超声表现与免疫组织化学因子之间有一定的相关性。有毛刺征及无淋巴结转移的乳腺癌有更高的ER阳性表达率,更适合内分泌治疗;血流丰富、有淋巴结转移者C-erbB-2阳性表达率高,预示肿块恶性程度高,预后不良。
Objective:To preliminarily study the correlation between manifestations of breast carcinoma on the color Doppler ult rasound and the expression of immunohistochemical factors ER, C-erbB-2 , and to provide more information and scientific evidence for the preoperative adjuvant therapy and for the evaluation of the prognosis1. Methods:103 patients with breast carcinoma on firmed by histopathology were involved in this study.The color Doppler ultrasound was performed in every case before therapy,and ER,C-erbB-2 were performed after operation. The correlation of the color Doppler ultrasonographic manifestations of breast carcinoma and the expressions of the three factors were analyzed. Results:1.There was a correlation between the size of breast carcinoma and the expression of ER,C-erbB-2 respectively.2.The positive expression rate of ER、C-erbB-2 in spiculated breast carcinoma was higher than non-spiculated. 3.The positive expression rate of C-erbB-2 was higher in patients with axillary lymph nodes metastasis,the positive expression rate of ER was lower . 4.The positive expression rate of C-erbB-2 was higher in breast carcinoma tissue of plentiful blood stream than lacking of blood stream. Conclusion:The manifestations of breast carcinoma on the ultrasound have some kind of correlation with expressions of immunohitochemical factors ER,C-erbB-2.The breast carcinoma with spiculated and axillary lymph nodes nonmetastasis are less malignant and more suitable for endocrine therapy; the breast carcinoma with plentiful blood flow and axillary lymph nodes metastasis have more possibility about the positive expression of C-erbB-2,indicating more malignant and prognosis badness.
Objective:To preliminarily study the correlation between manifestations of breast carcinoma on the color Doppler ult rasound and the expression of immunohistochemical factors ER, C-erbB-2 , and to provide more information and scientific evidence for the preoperative adjuvant therapy and for the evaluation of the prognosis1. Methods:103 patients with breast carcinoma on firmed by histopathology were involved in this study.The color Doppler ultrasound was performed in every case before therapy,and ER,C-erbB-2 were performed after operation. The correlation of the color Doppler ultrasonographic manifestations of breast carcinoma and the expressions of the three factors were analyzed. Results:1.There was a correlation between the size of breast carcinoma and the expression of ER,C-erbB-2 respectively.2.The positive expression rate of ER、C-erbB-2 in spiculated breast carcinoma was higher than non-spiculated. 3.The positive expression rate of C-erbB-2 was higher in patients with axillary lymph nodes metastasis,the positive expression rate of ER was lower . 4.The positive expression rate of C-erbB-2 was higher in breast carcinoma tissue of plentiful blood stream than lacking of blood stream. Conclusion:The manifestations of breast carcinoma on the ultrasound have some kind of correlation with expressions of immunohitochemical factors ER,C-erbB-2.The breast carcinoma with spiculated and axillary lymph nodes nonmetastasis are less malignant and more suitable for endocrine therapy; the breast carcinoma with plentiful blood flow and axillary lymph nodes metastasis have more possibility about the positive expression of C-erbB-2,indicating more malignant and prognosis badness.
引文
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[11]李雅洁.高频彩色多普勒超声综合指标诊断乳腺肿块的价值分析.中华现代临床医学杂志,2005 ,3 (15) :1570～1571.
[12]陈蓉,龚水根,张伟国,等.乳腺癌MRI形态学表现与病理、分子生物学相关性研究[J].中华放射学杂志,2004,38(6) :620-625.
[13]张嫣,郭庆禄,张江宇,等.乳腺癌钼靶X线表现与ER、PR及Her-2因子表达的相关性研究[J].影像诊断与介入放射学,2007,16(5) :207-211.
[14] [14] Lemevall A1 Imaging of axillary lymph node [ J ].Acta Oncol ,2000 ,39 (3) : 277-281.
[15]张龙方,李群,段云友等.乳腺癌腋窝淋巴结转移超声表现与病理对照[J ].中国医学影像技术, 2002 ,18 (6) :571-572.
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[18]王素梅,苏雁欣,田家玮,等.乳腺癌腋窝淋巴结转移的二维及彩色多普勒超声与病理对照研究[J ].中国医学影像技术, 2001, 17 (7) :661-662.
[19] Durna EM , Wren BG, Heller GZ , et al. Hormone replacement therapy after a diagnosis of breast cancer : cancer recurrence and mortality[J]. MJA , 2002 ,177 (7) :347-351.
[20] RuffinW K, Stacey.ClearA , Younger J , et al.Rationale for routine axillary dissection in carcinoma of the breast[J] .Am Coll Surg,1995, 180 (2) : 245-251.
[21]王素梅,苏雁欣,田家玮,等.乳腺癌腋窝淋巴结转移的二维及彩色多普勒超声与病理对照研究[J ].中国医学影像技术, 2001, 17 (7) :661-662.
[22] Fulford LG, Reis - Filho JS, Ryder K, et al. Basal - like gradeⅢinvasive ductal carcinoma of the breast: patternsofmatastasis and long - term survival. Breast Cancer Res, 2007, 9 (1) : R4
[23] Rodriguez - Pinilla SM, Sarrio D, Honrado E, et al.Prognostic significance of basal - like phenotype and fascin exp ression in node - negative invasive breast carcinomas.Clin Cancer Res, 2006, 12 (5) : 1533-1539.
[24] Durna EM , Wren BG, Heller GZ , et al. Hormone replacement therapy after a diagnosis of breast cancer : cancer recurrence and mortality[J ]. MJA , 2002 ,177 (7) :347-351.
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