用户名: 密码: 验证码:
结直肠癌患者术后生命质量及社会支持现状研究
详细信息    本馆镜像全文|  推荐本文 |  |   获取CNKI官网全文
摘要
目的
     1、评价武汉市结直肠癌患者术后的生命质量,并探讨其影响因素,为干预措施的制定提供科学依据。
     2、评价武汉市结直肠癌患者术后的社会支持状况,为结直肠癌患者术后社会支持状况的改善提供理论参考。
     3、评价QLQ-C30量表中文版的信度和效度。
     方法
     1、运用QLQ-C30量表中文版对结直肠癌患者术后生命质量进行测评,运用多元线性回归分析的方法筛选出生命质量影响因素。
     2、评价结直肠癌患者术后的社会支持状况,并采用t检验和方差分析筛选相关的影响因素。
     3、运用因子分析、相关分析等方法对量表的信度、效度进行评价。
     结果
     1、在功能子量表中,角色功能、情绪功能、躯体功能、认知功能得分较高,社会功能得分最低;在症状子量表中,疲乏得分最高,其余依次为疼痛、恶心与呕吐;在单项测量条目中,经济困难条目的得分最高。多元线性回归分析结果显示:症状数目、伴有其他疾病、社会支持得分、康复锻炼、文化程度是总体生命质量得分的影响因素;症状数目、伴有其他疾病、康复锻炼是功能领域总分的影响因素。
     2、结直肠癌患者术后得到的主观支持、社会支持总分随着年龄的增长逐渐下降;高学历患者获得较高的客观支持;在职患者得到的主观支持及社会支持总分高于离退患者;在婚患者得到的客观支持、主观支持及社会支持总分高于离异或丧偶患者;家庭月收入2000元以上患者得到的客观支持及社会支持总分高于家庭平均月收入低于2000元患者。
     3、QLQ-C30量表中文版各维度Cronbach’sα系数界于0.662~0.876,各维度的分半信度系数界于0.662~0.876之间。经探索性因子分析提取6个公因子,累计方差贡献率为69.06%,这6个公因子可合并成为2大方面,基本上与QLQ-C30量表的功能测量和症状测量2大理论构想一致。每个条目与其相应维度得分的相关性较高,与无关的维度得分的相关性较差。
     结论
     1、应从结直肠患者生命质量的影响因素出发,提供合理、有效的干预措施,提高患者的生命质量。
     2、结直肠癌患者术后社会支持的整体状况较好,但是患者对支持的利用度不是很理想;同时提示我们要更多的关注高龄、丧偶和离异及低文化程度低收入患者的社会支持状况。
     3、QLQ-C30(V3.0)中文版具有较好的信度和效度,可以用于我国结直肠癌患者生命质量的测评。
Objective:
     1 To evaluate the quality of life for patients with colorectal cancer in Wuhan who have lived more than one year after operation, and to explore the influencing factors of quality of life. According to the result, we can make interventions correctly. By analyzing the quality of life of patients with colorectal cancer in Wuhan, we can offer scientific basis of the development of interventions.
     2 To evaluate social support of patients with colorectal cancer in Wuhan who have lived more than one year after operation, According to the result, we can offer some theotetical references of the improvement of social support.
     3 To estimate the reliability and validity of the Chinese version of the QLQ-C30 scale.
     Methods:
     1 To measure the Quality of life with the QLQ-C30 scale. Then, find the influencing factors by analyzing the data with multiple linear regression analysis.
     2 To evaluate social support of colorectal cancer with t-test and univariate analysis.
     3 To assess reliability and validity of the QLQ-C30 scale with factor analysis and correlation analysis.
     Results:
     1 In function scale, the lowest function was social function; In symptom scale, the highest score was fatigue, followed by pain, nausea and vomiting; In the single symptom scale, the highest score was economic difficulty. Multiple linear regression analysis showed that the influencing factors of the general quality of life were the number of symptoms、comorbidities、social support、exercise rehabilitation and education backgroud. The influencing factors of the function scale were the number of symptoms、comorbidities and exercise rehabilitation.
     2 The subjective support and social support scores declined gradually with age; The influencing factors also included education backgroud、professional situation、matital status、average monthly income.
     3 The Cronbach’s alpha coefficient and split-half reliability coefficient of the Chinese version of QLQ-C30 were between 0.662 and 0.876. 6 common factors were extracted and the cumulative variance was 69.06%. 2 aspects can be merged from the 6 common factors, and the 2 aspects were essentially consistent with the 2 domains of the QLQ-C30. The coefficients between same domain were higher than the coefficients between different domains.
     Conclusion:
     1 The reasonable valid intervention can be offered according to the influencing factors of quality of life for colorectal cancer after operation. 2 The overall situaton of the social support of patients with colorectal cancer was good, but the situation of utilization was not very good. It suggested we should pay more attention to the old、widowed and divorced、low educational、poor level.
     3 The Chinese version of the QLQ-C30 had good reliablity and validity and can be used to assess the quality of life of Chinese colorectal patients.
引文
[1]郑树.结直肠肿瘤基础研究与临床实践[M].人民卫生出版社,2006,381.
    [2]杨玲,李连弟,陈育德,等.中国2000年及2005年恶性肿瘤发病死亡的估计与预测[J].中国卫生统计,2005,22(4):218-232.
    [3]郑晶泉,冯莉莉,阮晓楠,等.上海浦东新区大肠癌发病的流行病学研究[J].中国慢性病预防与控制,2003,11(3):110-135.
    [4]许岸高,姜泊,钟旭辉,等.广东地区近20年大肠癌临床特征的变化趋势[J].中华医学杂志,2006,86(4):272-275.
    [5]汪芬娟.杭州市萧山区大肠癌发病趋势[J].中国肿瘤.2004,13(11):696-698.
    [6] Kevin W. Smith NEea. Distinguishing between quality of life and health status in quality of life research: A meta-analysis [J]. Quality of Life Research. 1999, (8):447-459.
    [7] Michael Koller WL. Quality of life: a deconstruction for clinicians [J]. Journal of Royal Society of Medicine. 2002, 95:481-488.
    [8] B. Holzner GK, B. Sperner-Unterweger, et al. Quality of life measurement in oncology—a matter of the assessment instrument [J]. European Journal of Cancer. 2001, (37):2349-56.
    [9]李晓梅,许传志,陈明清,等.大肠癌患者的生命质量研究[J].中国行为医学科学, 2002,11(1):111-112.
    [10]中国抗癌协会.新编常见恶性肿瘤诊治规范(合订本)[M].北京:中国协和医科大学出版社,1999.
    [11]万崇华,陈明清,张灿珍,等.癌症患者生命质量测定量表EORTC qlq_c30中文版评介[J].实用肿瘤杂志,2005,20(11):353-355.
    [12] N. Luo CSLF, S.E. Lim, F. et al. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30): Validation of English version in Singapore [J]. Quality of Life Research. 2005,(14):1181-1186.
    [13] B. Holzner RKB, E.A. Hahn, et al. Equating EORTC QLQ-C30 and FACT-G scores and its use in oncological research [J]. European Journal Of Cancer. 2006, (42):3169-3177.
    [14] K. Kobayashi FT, S. Teramukai, et al. A Cross-validation of the European Organization for Research and Treatment of Cancer QLQ-C30 (EORTC QLQ-C30) for Japanese with Lung Cancer [J]. European Journal of Cancer. 1998, 34(6):810-815.
    [15] A. Montazeri IH, M. Vahdani, et al. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30): translation and validation study of the Iranian version [J]. Support Care Cancer. 1999, (7):400-406.
    [16] Yun YH PY, Lee ES, et al. Validation of the Korean version of the EORTC QLQ-C30 [J]. Quality of Life Research. 2004, 13(4):863-868.
    [17]邱彩锋,赵继军.QLQ_C30的应用及计分方法[J].国外医学护理学分册, 2005,24(11):701-703.
    [18]方积乾.卫生统计学(第五版) [M].北京:人民卫生出版社,2004,274 .
    [19] Glen C Balch ADM, Jose G Guillem, et al. Modern management of rectal cancer: A 2006 update [J]. World J Gastroenterol. 2006, 12(20):3186-3195.
    [20] Maliski SL KL, Krupski T, et al. Confidence in the ability to communicate with physicians among low-income patients with prostate cancer [J]. Urology. 2004, 64:329-334.
    [21] R.Schwarz AH. Reference data for the quality of life questionnaire EORTC QLQ-C30 in the general German population [J]. European Journal of Cancer. 2001, 37:1345-1351.
    [22]胡小华,龚幼龙,冯学山,等.大肠癌患者生命质量的多因素分析[J].中国卫生统计,2003,20(6):322-326.
    [23] Ramsey SD BK, Moinpour C, et al. Quality of life in long term survivors of colorectal cancer [J] American Journal of Gastroenterology. 2002, 97(5):1228-1234.
    [24]何小梅,刘丹萍,冯爽,等.多学科综合干预措施对大肠癌患者治疗后生存质量的影响[J].中华消化杂志,2006,26(5):337-338.
    [25]刘美兰,李玉珊,李春波.肿瘤康复俱乐部成员与住院肿瘤患者心理状况分析[J].上海铁道大学学报.,1999, 20(5):58-60.
    [26] Satariano WA HT, Tager IB. Living arrangements and participation in leisure-time physical activities in an older population [J]. Journal of Aging and Health . 2002, 14(4):427-451.
    [27] Michael YL KI, Berkman LF, et al. The persistent impact of breast carcinoma on functional health status - Prospective evidence from the nurses' health study[J]. Cancer. 2000, 89(11):2176-2186.
    [28] Berkman LF GT, Brissette I, et al. From social integration to health: Durkheim in the new millennium [J]. Social Science & Medicine. 2000, 51(6):843-857.
    [29]闻吾森,王义强.心理控制感和心理健康的关系研究[J].中国心理卫生杂志, 2000,14(4):258.
    [30] Sapp AL T-DA, Newcomb PA, et al. Social networks and quality of life among female long-term colorectal cancer survivors [J]. Cancer. 2003,98(8):1749-1758.
    [31]高莉萍.社会支持因素与癌症患者生活质量关系的研究[J].现代中西医结合杂志, 2007,16(8):1113-1114.
    [32]付岚,李俊英,李虹,等.社会支持与癌症患者生活质量的相关性研究及护理对策[J].中华护理杂志,2004,39(1):9-11.
    [33]沙立民,胡秀娟.癌症患者生活质量与社会支持因素的调查分析[J].Journal of Qiqihar Medical College,2003,24(1).
    [34]何小梅,樊晋川,朱昌明,等.恶性肿瘤患者生存质量的调查研究[J].中华医院管理杂志,2006,22(3):192-196.
    [35] Camilleri-Brennan J SRea. Prospective analysis of quality of life and survival following mesorectal excision for rectal cance [J]r. Br J Surg. 2001,8:1617-1622.
    [36] Lara FJP PA, Perucho AD. Study of factors related to quality of life in patients with locally advanced rectal cancer[J]. Revista Espanola De Enfermedades Digestivas. 2004, 96(11),746-752.
    [37]沈蓉蓉,毛雅芬.影响大肠癌术后生命质量的因素及护理对策.现代护理[J], 2001,7(12):11-12.
    [38] Young Ho Yun SHK, Kyoung Min Lee, et al. Age, sex, and comorbidities were considered in comparing reference data for health-related quality of life in the general and cancer populations [J]. Journal of Clinical Epidemiology. 2007,(60):1164-1175.
    [39] Pasetto LM FC, Compostella A, et al. Quality of life in elderly cancer patients[J]. European Journal Of Cancer. 2007, 43(10):1508-1513.
    [40] Jereczek-Fossa BA MH, Orecchia R. Radiotherapy-related fatigue [J]. Critical Reviews in Oncology Hematology. 2002, 41(3):317-325.
    [41] Dimeo FC TF, Raabe-Menssen C, et al. Effect of aerobic exercise and relaxation training on fatigue and physical performance of cancer patients after surgery[J]. A randomised controlled. Support Care Cancer, 2004, 12(11):774-779.
    [42] Jordhoy MS FP, Loge JH, et al. Quality of life in palliative cancer care: results from a cluster randomized trial [J]. Journal of Clinical Oncology. 2001, 19(18):3884-3894.
    [43] Oldervoll LM LJ, Paltiel H, et al. The effect of a physical exercise program in palliative care: a phase II study[J]. Journal of Pain and Symptom Management. 2006, 31(5).
    [44] Cohen SR LA. What determines the quality of life of terminally ill cancer patients from their own perspective? [J]. Journal of Palliative Care. 2002, 18(1):48-58.
    [45] Schmitz KH HJ, Courneya KS, et al. Controlled physical activity trials in cancer survivors: a systematic review and meta-analysis[J]. Cancer Epidemiology Biomarkers & Prevention. 2005, 14(7):1588-1595.
    [46] Pedersen BK SB. Evidence for prescribing exercise as therapy in chronic disease Scandinavian [J]. Journal of Medicine & Science in Sports. 2006, (16):3-63.
    [47] Oldervoll LM KS, Hjermstad M, et al. Physical exercise results in the improved subjective well-being of a few or is effective rehabilitation for all cancer patients? [J]. European Journal of Cancer. 2004,40(7):951-962.
    [48] KS. C. Exercise in cancer survivors: an overview of research. Medicine and Science in Sports and Exercise[J] .2003,35(11):1846-1852.
    [49] Dimeo FC TM, Bertz H, et al. Aerobic exercise in the rehabilitation of cancer patients after high dose chemotherapy and autologous peripheral stem cell transplantation [J]. Cancer. 1997, 79(9):1717-1722.
    [50] Crevenna R SM, Keilani M, et al. Aerobic exercise as additive palliative treatment for a patient with advanced hepatocellular cancer [J]. Supportive Care in Cancer. 2003, 11(2):120-122.
    [51] Porock D KL, Tinnelly K, et al. An exercise intervention for advanced cancer patients experiencing fatigue: a pilot study[J]. Journal of Palliative Care. 2000, 16(3):30-36.
    [52]陈峰.医用多元统计方法[M].北京:中国统计出版社; 2000.
    [53]赵松山,白雪梅.关于多重共线性检验方法的研究[J].中国煤炭经济学院学报, 2001,15(4):296-300.
    [54]侯文,刘素丽.多重共线性数据的一种诊断方法[J].中国卫生统计, 2000,17(5):285-286.
    [55]李玲,饶克勤,王启俊.肿瘤危险因素的筛选与多重共线性的诊断和处理[J].中国卫生统计, 1999(03).
    [56]刘国旗.多重共线性的产生原因及其诊断处理[J].合肥工业大学学报(自然科学版), 2001,24(4):607-610.
    [57]王伟,田庆伟.建立回归模型应注意避免多重共线性[J].数理医药学杂志, 1999,12(4):309-310.
    [58]舒晓惠,刘建平.利用主成分回归法处理多重共线性的若干问题[J].统计与决策.,2004(10):25
    [59]杨杰,吴中如.观测数据拟和分析中的多重共线性问题[J].四川大学学报, 2005,37(5):19-24.
    [60]何小梅,付饶,黄玉,等.肠癌患者心理健康和家庭社会功能与生活质量的多因素分析[J].中国临床康复,2005,9(28):80-82.
    [61] Lobchuk MM DL. Symptom experiences: Perceptual accuracy between advanced-stage cancer patients and family caregivers in the home care setting [J]. Journal of Clinical Oncology. 2002, 20(16):3495-3507
    [62] Repetto L A-CG, Gallo C, et al. Quality of life in elderly cancer patients [J]. Annals of Oncology. 2001, 12(3):49-52.
    [63]安胜利,陈平雁.量表的信度及其影响因素[J].中国临床心理学杂志,2001,9(4):315-318.
    [64]康德英,王家良,洪旗.健康相关生存质量及其评价方法[J].中华医学杂志, 2001,81(13):829-830.
    [65] Huang CC LH, Sung YC, et al. Quality of life of patients with gastric cancer in Taiwan: Validation and clinical application of the Taiwan Chinese version of the EORTC QLQ-C30 and EORTC QLQSTO22[J]. Psycho-Oncology. 2000,16(10):945-949.
    [66] Huang CC LH, Sung YC, et al. Quality of life of patients with gastric cancer in Taiwan: Validation and clinical application of the Taiwan Chinese version of the EORTC QLQ-C30 and EORTC QLQSTO22[J]. PSYCHO-ONCOLOGY 2007, 16(10):945-949.
    [67] McPherson RS HD, Alexander M, et al. Dietary assessment methods among school-aged children: Validity and reliability [J]. Preventive Medicine. 2000, 31(2):11-33.
    [68] Chrispin PS SH, Rogers J, et al. Short Form 36 in the intensive care unit: Assessment of acceptability, reliability and validity of the questionnaire [J]. Anaesthesia. 1997, 52(1):15-23.
    [69] Yao G CC, Yu CF, et al. . Development and verification of validity and reliability of the WHOQOL-BREF Taiwan version[J]. Journal of the Formosan Medical. 2002, 101(5):342-351.
    [70] Shu XO YG, Jin F, et al. Validity and reproducibility of the food frequency questionnaire used in the Shanghai Women's Health Study[J]. European Journal of Clinical Nutrition. 2004, 58(1):17-23.
    [71]马文军,潘波.问卷的信度和效度以及如何用Sas软件分析[J].中国卫生统计,2000,17(6):364-365.
    [72]姜宝法,刘春晓,崔永春,等. EORTC QLQ-C30的信度、效度研究[J].中国临床心理学杂志,2005,13(1):31-36.
    [1]王家良.临床流行病学:临床科研设计、衡量与评价[M].上海:上海科学技术出版社, 2001.
    [2]柳青.生存质量评价[M].孙振球.医学统计学(第二十四章).北京:人民卫生出版社, 2002. 397.
    [3]方积乾.生存质量测定方法及应用[M].北京:北京医科大学出版社, 2000.
    [4]武秋林,马宏民,岑秀芬,等.广州市1994~2002年妇女乳腺疾病监测[J].中华流行病学杂志, 2003, 24(12): 1159.
    [5] Hacker, E. Quantitative measurement of quality of life in adult patients undergoing bone marrow transplant or peripheral blood stem cell transplant: a decade in review[J]. Oncology Nursing Forum, 2003, 30 (4): 613–629.
    [6] University of Toronto Website. (n.d.). The quality of life model. Retrieved January 30, 2004; from http://www.utoronto.ca/qol/concepts/htm
    [7]贾恩志,徐耀初,沈洪兵,等. NHP量表对恶性肿瘤患者生命质量的评价[J].中国肿瘤, 1999, 8(12): 566-568.
    [8] Sprangers MA, Groenvold M, Arraras JI, et al. The European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field study [J]. J Clin Oncol, 1996, 14: 2756–2768.
    [9] Fayers P, Bottomley A. Quality of life research within the EORTC——the EORTC QLQ-C30 [J]. European Journal of Cancer, 2002,38: 125-133
    [10] Norum J.Quality of Life in Colorectal Cancer Patients Treated with Doxorubicin and a Multi-drug Resistance (MDR) Modulator (SDZ-833): a Pilot Study[J]. Anticancer Res, 1998,18(4):2933-2936.
    [11] Anderson H, Palmer MK.Measuring Quality of Life: Impact of Chemotherapy for Advanced Colorectal Cancer.Experience from Two Recent Large PhaseⅢTrials [J].Br J Cancer,1998,77(2):9-14.
    [12] Hill M,Norman A,Cunningham D,et al.Impact of Protracted Venous Infusion Fluorouracil with or withput Interferon Alfa-2b on Tumor Response,Surivival,and Quality of Life in Advanced Colorectal Cancer[J].J Clin Oncol,1995,13(9):2317-2323.
    [13] Ulander K,Jeppsson B,and Grahn G..Quality of Life and Independence in Activities of Daily Living Preoperatively and at Follow-up in patients with Colorectal Cancer[J].Support Care Cancer,1997,5(5):402-409
    [14]姜宝法,刘春晓,崔永春,等. EROTC QLQ-C30的信度、效度研究[J].中国临床心理学杂志, 2005, 13(1): 31-36.
    [15]李小梅,许传志,万崇华,等.大肠癌患者的生命质量研究[J].中国行为医学科学, 2002, 11(1): 111-112.
    [16] Brady MJ, Cella DF, Mo F,et al. Reliability and validity of the Functional Assessment of Cancer Therapy—Breast quality-of-life instrument.J Clin Oncol, 1997; 15: 974–986.
    [17] Overcash J, Extermann M, Parr J, et al. Validity and reliability of the FACT-G scale for use in the older person with cance[J]r. Am J Clin Oncol, 2001,24(6): 591-596.
    [18] Juan J Dapueto, Carla Francolino, Liliana Servente, et al. Evaluation of the Functional Assessment of Cancer Therapy-General (FACT-G) Spanish Version 4 in South America: Classic Psychometric and Item Response Theory Analyses[J]. Health Qual Life Outcomes, August 2003, 1(1): 32.
    [19] Thomas BC, Pandey M, Ramdas K, et al. FACT-G: reliability and validity of the Malayalam translation [J]. Qual Life Res, February 2004, 13(1): 263-269.
    [20] Conroy T, Mercier M, Bonneterre J, et al. French version of FACT-G: Validation and comparison with other cancer-specific instruments [J]. European Journal of Cancer, 2004, 40: 2243-2252.
    [21]万崇华,孟琼,汤学良,等.癌症患者生命质量测定量表FACT-G中文版评价[J].实用肿瘤杂志, 2006, 21(1): 77-80.
    [22]李晓梅,许传志,万崇华,等.大肠癌患者的生命质量研究[J].中国行为医学科学,2002,11(1):111-112.
    [23] Whynes DK,Neilson AR,Robinson MH,et al. Colorectal Cancer Screening and Quality of Life [J]. Qual Life Res, 1999, 3(3):191-198.
    [24] Kjeldsen BJ,Thorsen H,Whalley D,et al.Influence of Follow-up on Health-related Quality of Life after Radical Surgery for Colorectal Cancer[J]. Scand J Gastroenterol, 1999,34(5):509-515.
    [25] Anderson H, Palmer MK.Measuring Quality of Life: Impact of Chemotherapy for Advanced Colorectal Cancer. Experience from Two Recent Large PhaseⅢTrials [J]. Br J Cancer, 2000, 77(2):9-14.
    [26]万崇华,孟琼,罗家洪,等.癌症患者生命质量测定量表体系共性模块的研制(一):条目筛选及共性模块的形成[J].癌症,2007,26(2):113-117.
    [27]万崇华,孟琼,罗家洪,等.癌症患者生命质量测定量表体系共性模块的研制(二):条目筛选及共性模块的形成[J].癌症,2007,26(3):225-229.
    [28]陈增蓉,李卡,印义琼,等.120例直肠癌结肠造口病人生存质量的分析[J].四川大学学报(医学版),2005,36(3):445-446.
    [29] Hermanek P, Sobin LH. Colorectal Carcinoma [A]. In: Hermanek P, Gospodarowicz MK, Henson DE, et al. Prognostic factors in cancer[J]. New York: Springer-Verlag: 1995. 64-79.
    [30] Levine MN, Ganz PA. Beyond the development of quality of life instruments: where do we go from here? [J]. J Clin Oncol, 2002, 20: 2215–2216.
    [31] Maisey NR, Norman A, Watson M, et al. Baseline quality of life predicts survival in patients with advanced colorectal cancer[J]. Eur J Cancer, 2002, 38: 1351–1357.
    [32] Montazeri A, Milroy R, Hole D, et al. Quality of life in lung cancer patients: as an important prognostic factor [J]. Lung Cancer, 2001, 31: 233–240.
    [33] Rasanen JV, Niskanen MM,MiettinenP, et al. Health-related quality of life before and after gastrointestinal surgery [J]. Eur J Surg 2001,167:419-425.
    [34] Glise H, Hallerback B, Johansson B. Quality-of-life assessments in evaluation of laparoscopic Rosetti fundoplication [J]. Surg Endosc, 1995,9:183-185.
    [35] Velanovich V. Comparison of symptomatic and quality of Life outcomes of laparoscopic versus open antireflux surgery [J]. Surgery, 1999,126:782-788.
    [36] Ramsey SD, Berry K, Moinpour C,et al.Quality of life in long term survivors of colorectal cancer[J].Am J Gastroenterol.2002,97:1228-1234.
    [37] Kitagawa Y,Kitano S,Kubota T, et al. Minimally invasive surgery for gastric cancer-toward a confluence of two major streams: a review[J]. Gastric Cancer. 2005, 8:103-110.
    [38] Velanovich V. Laparoscopic vs open surgery:a preliminary comparison of quality-of-life outcomes[J]. Surg Endosc.2000, 14:16-21.
    [39] Weeks JC, Nelson H, Gelber S, et al. Short-term quality-of-life outcomes following laparoscopic-asisted colectomy vs open colectomy for colon cancer: a randomized trial [J]. IAMA, 2002, 287:321-328.
    [40] Engel J, Kerr J, Schlesinger-Raab A, Eckel,Sauer H,Holzel D. Quality of life in rectal cancer patients: a four-year prospective study[J]. Ann Surg, 2003, 238:203-213.
    [41] Schmidt CE, BestmannB, Kuchler T, et al.Factors influencing sexual function in patients with rectal cancer [J]. Int J Impot Res, 2005, 17:231-238.
    [42] Guren MG, Eriksen MT, Wiig JN, et al.Quality of life and functional outcome following anterior or abdominoperineal resection for rectal cancer[J]. Eur J Surg Oncol, 2005, 31:735-742.
    [43] Rauch P, Miny J,Conroy T,et al.Quality of life among disease-free survivors of rectal cancer[J].J Clin Oncol, 2004,22:354-360.
    [44] Pachler J, Wille-Jorgensen P. Quality of life after rectal resection for cancer, with or without permanent colostomy [J]. Cochrane Database Syst Rev, 2004.
    [45] Korolija D, Sauerland S, Wood, et al. Evaluation of quality of life after laparoscopic surgery [J]. Surg Endosc, 2004, 18:879-897.
    [46]秦海霞,南克俊,杨光.老年大肠癌生存分析[J].现代肿瘤医学,2003,11(5):357- 359.
    [47]吕美霞,段琼红,施侣元,等.恶性淋巴瘤患者生存质量影响因素研究[J].中华流行病学杂志,2006,27(6)535-539.
    [48]何小梅,付饶,黄玉清,等.肠癌患者心理健康和家庭社会功能与生活质量的多因素分析[J].中国临床康复,2005,9(28):80-82.
    [49]沈蓉蓉,毛雅芬.影响大肠癌术后生命质量的因素及护理对策[J].现代护理,2001,7(12):11.
    [50]何小梅,樊晋川,朱昌明,等.恶性肿瘤患者生存质量的调查研究[J].中华医院管理杂志,2006,22(3):192-195.
    [51]覃惠英,郑美春,温咏珊,等.结肠造口患者生活质量的影响因素分析[J].癌症,2004,23(11):1589-1592.
    [52]何小梅,刘丹萍,冯爽,等.多学科综合干预对大肠癌患者治疗后生存质量的影响[J].中华消化杂志,2006,26(5):337-338.
    [53] Helgeson VS, Cohen S, Schilz R,et al.Group support interventions for women with breast cancer:who benefits from what? [J]. Health Psychol, 2000, 19:107-114
    [54] Lesley Fallowfield, David Cella, Jack Cuzick, et al. Quality of Life of Postmenopausal Women in the Arimidex, Tamoxifen, Alone or in Combination (ATAC) Adjuvant Breast Cancer Trial[J]. J Clin Oncol, 2004, 22: 4261-4271.
    [55]何小梅,樊晋川,朱昌明,等.恶性肿瘤患者生存质量的调查研究[J].中华医院管理杂志,2006,22(3):192-195.
    [56]王春芳,胡小华,沈渊,等.大肠癌患者住院费用及其影响因素[J].中国肿瘤,2004,13(12):767-769
    [57]覃惠英,郑美春,温咏珊,等.结肠造口患者生活质量的影响因素分析[J].癌症,2004,23(11):1589-1592
    [58]何小梅,付饶,黄玉清,等.肠癌患者心理健康和家庭社会功能与生活质量的多因素分析[J].中国临床康复,2005,9(28):80-82.
    [59]曹冬凌.心理行为干预对大肠癌化疗患者生命质量的影响[J].中国医药导报,2006,3(26):38-39.
    [60]何小梅,刘丹萍,冯爽,等.多学科综合干预对大肠癌患者治疗后生存质量的影响[J].中华消化杂志,2006,26(5):337-338.
    [61]沈蓉蓉,毛雅芬,朱建萍,等.大肠癌术后病人心理问题分析及护理干预对策[J].中华国际护理杂志,2002,3(1):13.
    [62]曾丽容,黄锦萍,柯欣.社会支持对结直肠癌患者生命质量的影响[J].国际医药卫生导报,2006:24-25.
    [63] Lobchuk MM DL. Symptom experiences: Perceptual accuracy between advanced-stage cancer patients and family caregivers in the home care setting [J]. Journal of Clinical Oncology. 2002, 20(16):3495-507.
    [64] Repetto L A-CG, Gallo C, et al. Quality of life in elderly cancer patients[J]. Annals of Oncology. 2001, 12(3):49-52.
    [65]陈增蓉,李卡,印义琼,等.120例直肠癌结肠造口病人生存质量的分析[J].四川大学学报(医学版),2005,36(3):445-446.
    [66]寇京莉,冯新玮,韩斌如.结肠造口灌洗对直肠癌Miles术后病人生活质量的影响[J].护理学杂志,2003,18(10):757.
    [67]陈琳,江惠娟,陈增春.营养因素对大肠癌患者生存质量的影响[J].中国肿瘤,2005,14(10):650-651.
    [68]胡小华,龚幼龙,冯学山,等.大肠癌患者生命质量的多因素分析[J].中国卫生统计,2003,20(6):322-326.
    [69]何小梅,付饶,黄玉清,等.肠癌患者心理健康和家庭社会功能与生活质量的多因素分析[J].中国临床康复,2005,9(28):80-82.

© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号

地址:北京市海淀区学院路29号 邮编:100083

电话:办公室:(+86 10)66554848;文献借阅、咨询服务、科技查新:66554700