光声技术用于层析成像的研究
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摘要
光声技术是一种高灵敏度的无损伤检测技术,近年已成为一个研究热点。光声技术在生物医学领域中的应用为临床诊断提供了一种新的研究手段—光声层析成像。光声层析成像结合了纯光学成像和纯超声成像的优点,可以提供高分辨率和高对比度的组织成像。作为新一代的生物医学影像技术,光声成像能够有效的进行生物组织结构和功能成像,为研究生物组织的形态结构,生理特征,病理特征,代谢功能等提供了重要手段。本文针对光声成像技术进行了系统设计、硬件搭建、软件编程和初步的理论、实验研究,主要包括:
1、光声技术结合了光学与超声的优点,具有分辨率高、抗干扰能力强等特点。本文在理论上进行了初步的多环光声成像探测技术研究,论述了多环光声探测成像技术的基本原理、重建算法;
2、使用红外半导体激光器(950nm)和多环复合材料超声探测器等器件搭建了一套光声层析成像系统;
3、利用GPIB-USB和PCI-1750构架了多环阵列光声传感器信号采集系统,使用LabVIEW软件进行了算法和去噪处理软件的编制,实验表明该系统软硬件工作正常,能够进行光声信号的探测;
4、由于多环探测技术在轴向探测,尤其是定量探测上比阵列探测、单环、双环探测技术具有优势,本文设计了多波长共聚焦微流控芯片检测系统,并申请获批了专利。
Photoacoustic technique which is a highly sensitive and noninvasive detecting technology, has become a hot research field in recent years.Photoacoustic technique has provided a new research approach called Photoacoustic Tomography(PAT) for clinical diagnosis in biomedical application. PAT combines advantages of both ultrasound and optical imaging,can provide high ultrasonic resolution and high optical cantrast tissue images.As the next generation successful imaging techniques in biomedical application,PAT can provide an effective approach of tissue structure and functional images to study the architechtures,physiological and pathological properties and metabolism of biological tissues. This paper mainly includes four parts.
1.Photoacoustic technique combines the advantages of optical and ultrasound,it has high resolution, anti-interference ability and so on. The preliminary study of multi-ring photoacoustic imaging detection technology has been discussed in this paper, the fundamental principles and reconstruction algorithm of the multi-ring photoacoustic detection imaging have been introduced.
2.A photoacoustic tomography system has been established by using infrared diode laser (950nm),multi-ring annular photoacoustic transducer made from composite material and other devices.
3.The multi-ring photoacoustic sensor array signal acquisition system based on GPIB-USB and PCI-1750 have been designed. Using LabVIEW software algorithm and the noise of the establishment of software, hardware and software experiments show that the system works properly, capable of photoacoustic signal detection;
4.Multi-ring technology has more advantages than single-ring,double-ring detection technology in the axial detection, in particular the quantitative detection of photogenic.A multi-wavelength confocal microfluidic chip detection system has been designed in this thesis, and we have filed an application for a patent.
1、光声技术结合了光学与超声的优点,具有分辨率高、抗干扰能力强等特点。本文在理论上进行了初步的多环光声成像探测技术研究,论述了多环光声探测成像技术的基本原理、重建算法;
2、使用红外半导体激光器(950nm)和多环复合材料超声探测器等器件搭建了一套光声层析成像系统;
3、利用GPIB-USB和PCI-1750构架了多环阵列光声传感器信号采集系统,使用LabVIEW软件进行了算法和去噪处理软件的编制,实验表明该系统软硬件工作正常,能够进行光声信号的探测;
4、由于多环探测技术在轴向探测,尤其是定量探测上比阵列探测、单环、双环探测技术具有优势,本文设计了多波长共聚焦微流控芯片检测系统,并申请获批了专利。
Photoacoustic technique which is a highly sensitive and noninvasive detecting technology, has become a hot research field in recent years.Photoacoustic technique has provided a new research approach called Photoacoustic Tomography(PAT) for clinical diagnosis in biomedical application. PAT combines advantages of both ultrasound and optical imaging,can provide high ultrasonic resolution and high optical cantrast tissue images.As the next generation successful imaging techniques in biomedical application,PAT can provide an effective approach of tissue structure and functional images to study the architechtures,physiological and pathological properties and metabolism of biological tissues. This paper mainly includes four parts.
1.Photoacoustic technique combines the advantages of optical and ultrasound,it has high resolution, anti-interference ability and so on. The preliminary study of multi-ring photoacoustic imaging detection technology has been discussed in this paper, the fundamental principles and reconstruction algorithm of the multi-ring photoacoustic detection imaging have been introduced.
2.A photoacoustic tomography system has been established by using infrared diode laser (950nm),multi-ring annular photoacoustic transducer made from composite material and other devices.
3.The multi-ring photoacoustic sensor array signal acquisition system based on GPIB-USB and PCI-1750 have been designed. Using LabVIEW software algorithm and the noise of the establishment of software, hardware and software experiments show that the system works properly, capable of photoacoustic signal detection;
4.Multi-ring technology has more advantages than single-ring,double-ring detection technology in the axial detection, in particular the quantitative detection of photogenic.A multi-wavelength confocal microfluidic chip detection system has been designed in this thesis, and we have filed an application for a patent.
引文
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[2] Veingerov,M.L,Ilkl Akad Nauk SSSR,19,687(1983)
[3]MagdalenaC.Pilatou,RoyG.M.Kolkman,Photoacoustic imaging of Blood Perfusion in Tissue and Phantons.Proe.SPIE,2001,4256,28~33
[4]SuzukiK, YamashitaY,OhtaK et a1.Quantitative measurement of optical parameters in normal breasts using time.Resolved Spectroscopy in vivo results of 30 Japanesewomen. JbiomedOpt 1996,1(3):330~334
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[7]Sihua Yang, Da Xing, Quan Zhou et al.. High-Resolution and noninvasive photoacoustic brain imaging for monitoring of the cerebrovascular blood flow and blood occlusion[J]. Appl. Phys. Lett.
[8]宋智源,刘英杰,王瑞康等.光声技术[J].中国激光医学杂志,2006,15:127~128
[9]Esenaliev RO.Photoacoustic technique for noninvasive monitoring of blood oxygenation:a feasibility study[J].App Optics,2002,41:4722~4731
[10]周篪声,郭周义,吴宏越.癌变组织的光声谱研究[J].光谱学与光谱分析,1995,15:35~38
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[12]Lvming Zeng, Da Xing, Huaimin Gu,et al. Liangzhong Xiang, High antinoise photoacoustic tomography based on a modified filtered backprojection algorithm with combination wavelet.Med. Phys., 2007, 34(2):556~563
[13]Liangzhong Xiang, Da Xing, Huaimin Gu, Diwu Yang, Sihua Yang, Lvming Zeng, Chen R. Wei, Real-Time Optoacoustic Monitoring of Vascular Damage during Photodynamic Therapy Treatment of Tumor.J. Biomed. Opt., 2007, 21(1), 014001
[14]Hao F Zhang, George Stoica, Lihong V Wang,et al. Functional photoacoustic microscopy for high-resolution and non-invasive in vivo imaging. Nature Biotechnology, 2006, 24(7), 848~851
[15]Y. X. Su, F. Zhang, K. X. Xu,et al. A photoacoustic tomography system for imaging of biological tissues.J. Phys. D: Appl. Phys., 2005, 38:2640~2644
[16]Sihua Yang, Da Xing, Yeqi Lao,et al. Noninvasive monitoring of traumatic brain injury and post-traumatic rehabilitation with laser-induced photoacoustic imaging.Appl. Phys. Lett., 2007, 90, 243902
[17] Edell S. L., Eisen M. D..Current imaging modalities for the diagnosis of breast cancer[J]. Del Med J., 1999, 71(9):377~382
[18]Karabutov A. A., Andreev V. G., Bell B et al.. Optoacoustic images of early cancer in forward and backward modes [C].Proc. SPIE, 2001, 4434: 13～27
[19]Savateeva, Elena V., Karabutov, et al.. Noninvasive detection and staging of oral cancer in vivo with confocal optoacoustic tomography[C]. Proc. SPIE, 2000, 3916: 55～66
[20]Anderrv VG, Ponomaryov AE, Henrichs PM et al.. Detection of prostate cancer with optoacoustic tomography:feasibility and modeling[C]. Proc. SPIE, 2003, 4960:45～57
[21] LiangZhong Xiang, Da Xing, HuaiMin Gu et al.. In vivo monitoring of neovascularization in tumour angiogenesis by photoacoustic tomography[J]. Chin. Phys. Lett., 2007, 24(3): 751~754
[22] Liangzhong Xiang, Da Xing, Huaimin Gu et al.. Real -time optoacoustic monitoring of vascular damage during photodynamic therapy treatment of tumor[J]. J. Biomed. Opt., 2007, 12(1):014001
[23]Xueding Wang, Yongjiang Pang, Geng Ku et al.. Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain[J]. Nature Biotechnology, 2003, 21(7): 803~806
[24] Esenaliev R, Larina 1 V,Latin,et a1.Op toacoustic technique for noninvasive monitoring of blood oxygenation:a feasability stody.Applied Op tics,2002,41(22):4722~4731
[25] Lvming Zeng, Da Xing, Huaimin Gu,et al. Liangzhong Xiang, High antinoise photoacoustic tomography based on a modified filtered backprojection algorithm with combination wavelet.Med. Phys., 2007, 34(2):556~563
[26] Kolkman R GM, Erwin H,Wiendelt S, et al . In vivo photoacoustic imaging of blood vessels using an extreme-narrow aperture sensor[ J ]. IEEE Journal of selected t op ics in quantum electr onics, 2003, 9 (2) : 343~346
[27] Kolkman R GM, John H GM K, Erwin H, et al . Photoacoustic determination of blood vessel diameter[J]. Phys Med Biol,2004, 49: 4745~4756
[28] Kolkman R GM,Hondebrink E,STEENBERGENW,et al . Phot oacoustic imaging of blood vessels with a double-ring sensor featuring a narrow angular aperture[J]. J Biomed Op tics, 2004, 9 (6) : 1327~1335
[29] Diwu Yang, Da Xing, Yi Tan et al. Integrative prototype B-scan photoacoustic tomography system based on a novel hybridized scanning head[J]. Appl. Phys. Lett., 2006, 88: 17410
[30]T.Bowen,Radiation-induced thermoaeoustic soft tissue imaging,Proc,IEEE Ultrason,SymP.1981,2:817~822
[31]王维江,朱延彬.光声光谱技术在生物医学领域的发展与应用.激光生物学报, 1997, 6(1):1024~1029.
[32] U. Krüger, M. Kraenzmer, O. Strindehag. Field Studies in the Indoor Air Quality by Photoacoustic Spectroscopy. Environment International, 1995, 21(6): 791~801.
[33] N. Gaft, I. Trabjerg, R. Reisfeld and G. Panezer. Absorption of molecular oxygen and water in apatite by photoacoustic spectroscopy. Spectrochimica Acta Part A, 1998, 54:1721.
[34]郭萍,刘礼恩,刘琴.白血病人血流的光声光谱.光谱学与光谱分析, 2000, 20(3):465~469
[35] A. A. Oraevsky, S. L. Jacques, R. O. Esenaliev, F. K. Tittel. Laser-based optoacoustic imaging in biological tissues. Proc. SPIE, 1994, 2134A: 122~128
[36] R. A. Kruger and P. Y. Liu. Photoacoustic ultrasound: pulse production and detection in 0.5% Liposyn. Medical Physics, 1994, 21(7): 1179~1184
[37] A. Oraevsky, R. O. Esenaliev, S. L. Jacques,et al. Lateral and z-axial resolution in laser optoacoustic imaging with ultrasonic transducers. Proc. SPIE, 1995, 2389:198~208
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